Groote Schuur Hospital and University of Cape Town 2 articles published in JoVE Medicine Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources Laurence Edward Court1, Ajay Aggarwal2, Hester Burger3, Carlos Cardenas4, Christine Chung1, Raphael Douglas1, Monique du Toit5, Anuja Jhingran1, Raymond Mumme1, Sikudhani Muya6, Komeela Naidoo5, Jerry Ndumbalo6, Tucker Netherton1, Callistus Nguyen1, Adenike Olanrewaju1, Jeannette Parkes3, Willie Shaw7, Christoph Trauernicht5, Melody Xu8, Jinzhong Yang1, Lifei Zhang1, Hannah Simonds9, Beth M. Beadle10 1The University of Texas MD Anderson Cancer Center, 2Guy’s and St. Thomas’ Hospital, 3Groote Schuur Hospital and University of Cape Town, 4University of Alabama at Birmingham, 5Tygerberg Hospital and Stellenbosch University, 6Ocean Road Cancer Institute, 7University of the Free State, 8University of California-San Francisco, 9University Hospitals Plymouth NHS Trust, 10Stanford University This protocol describes a series of automated tools designed for high-quality radiotherapy autocontouring and autoplanning that are being packaged into a web-based service to maximize robustness and scalability while minimizing operational costs. Medicine Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System Laurence E. Court1, Kelly Kisling1, Rachel McCarroll1, Lifei Zhang1, Jinzhong Yang1, Hannah Simonds2, Monique du Toit2, Chris Trauernicht2, Hester Burger3, Jeannette Parkes3, Mike Mejia4, Maureen Bojador4, Peter Balter1, Daniela Branco1, Angela Steinmann1, Garrett Baltz1, Skylar Gay1, Brian Anderson1, Carlos Cardenas1, Anuja Jhingran5, Simona Shaitelman5, Oliver Bogler6, Kathleen Schmeller7, David Followill1, Rebecca Howell1, Christopher Nelson1, Christine Peterson8, Beth Beadle5,9 1Department of Radiation Physics, University of Texas MD Anderson Cancer Center, 2Department of Radiation Oncology, Stellenbosch University and Tygerberg Hospital, 3Departments of Radiation Oncology and Medical Physics, Groote Schuur Hospital and University of Cape Town, 4Department of Radiation Oncology, University of Santo Tomas Hospital, Benavides Cancer Institute, 5Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, 6Academic Affairs, University of Texas MD Anderson Cancer Center, 7Department of Gynecological Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, 8Department of Biostatistics, University of Texas MD Anderson Cancer Center, 9Department of Radiation Oncology, Stanford University Radiation therapy is a highly complex cancer treatment that requires multiple specialists to create a treatment plan and provide quality assurance (QA) prior to delivery to a patient. This protocol describes the use of a fully automated system, the Radiation Planning Assistant (RPA), to create high-quality radiation treatment plans.