Zibo Municipal Hospital 1 article published in JoVE Medicine The Efficacy and Underlying Pathway Mechanisms of ShiDuGao Treatment for Anus Eczema Based on GEO Datasets and Network Pharmacology Song Wang*1,2,3, Wanyi Xiao*1,2, Anqi He1,2, Jinyan Jia1,2, Gang Liu1,2 1Department of General Surgery, Tianjin Medical University General Hospital, 2Tianjin General Surgery Institute, 3Department of General Surgery, Zibo Municipal Hospital This investigative effort sought to elucidate the mechanism of topical drug administration using a synergistic integration of network pharmacology and gene expression omnibus (GEO) datasets. This article evaluated the feasibility, target, and mechanism of ShiDuGao (SDG) in treating anus eczema.