GlaxoSmithKline 1 article published in JoVE Immunology and Infection A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii Jennifer L. Hoover1, Thomas F. Lewandowski1, Cindy L. Mininger1, Christine M. Singley1, Scott Sucoloski1, Stephen Rittenhouse1 1Antibacterial Discovery Performance Unit, GlaxoSmithKline A method for establishing lung infections in immunocompetent rodents is described. With proficiency, this method can be performed quickly and easily to induce stable infection with many isolates of S. pneumoniae, H. influenzae, P. aeruginosa, K. pneumoniae and A. baumannii.