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Neuroscience

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JoVE Journal Neuroscience
Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro
 

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro

Article DOI: 10.3791/2910-v • 16:13 min • June 13th, 2011
June 13th, 2011 •
*1, *1, 2, 1
1Department of Neurology and Committee on Neurobiology, The University of Chicago Medical Center, 2Department of Neurology, The University of Chicago Medical Center
* These authors contributed equally

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résumé
Automatic Translation

Migraine and its transformation to chronic migraine are immense healthcare burdens in need of improved treatment options. We seek to define how neural immune signaling modulates the susceptibility to migraine, modeled in vitro using spreading depression in hippocampal slice cultures, as a means to develop novel therapeutic targets.

Tags

Neural Immune Signaling Episodic Migraine Chronic Migraine Spreading Depression In Vitro Modeling Therapeutic Targets Migraine Aura Migraine Pain Electrical Activity Pain Perception Studies Trigeminal Nociceptive Pathways Cellular Mechanisms Neural Circuit Mechanisms Acute Slices Hippocampal Slice Cultures
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