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Modified Technique for Coronary Artery Ligation in Mice
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Journal JoVE Médecine
Modified Technique for Coronary Artery Ligation in Mice

Modified Technique for Coronary Artery Ligation in Mice

DOI:
10.3791/3093-v

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05:47 min

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March 29, 2013

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, ,
1Wallenberg Laboratory,Sahlgrenska Academy, University of Gothenburg

Chapitres

  • 00:05Titre
  • 01:14Coronary Artery Ligation Surgery
  • 04:06Results: ECGs and Echocardiograms after Myocardial Infarction
  • 05:29Conclusion

Summary

Traduction automatique

Traduction automatique

The surgical procedure used to induce experimental myocardial infarction in mice begins with left thoracotomy between the third and the fourth ribs in order to visualize the anterior surface of the heart and left lung. The left coronary artery is ligated, the chest is closed and the mouse is allowed to recover spontaneously.

Tags

Coronary Artery LigationModified TechniqueMiceMyocardial InfarctionPathophysiologyMyocardial IschemiaTherapeutic TargetsPreclinical ResearchLeft Coronary ArteryAnesthetizedIntubatedVentilatorArtificial VentilationChest IncisionPectoralis Major MuscleThoracotomyInfarct SizePostoperative Analgesia

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