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CYP2D6动物模型:如何诱导小鼠自身免疫性肝炎
Journal JoVE
Médecine
This content is Free Access.
Journal JoVE Médecine
The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
DOI:

09:03 min

February 03, 2012

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Chapitres

  • 00:05Titre
  • 01:43Intravenous Injection of Ad-2D6 into the Opthalmic Sinus
  • 02:31Mouse Liver Perfusion
  • 04:20Isolation of Liver Lymphocytes
  • 05:39Representative Liver Morphology and Histology in hCYP2D6-infected Mice
  • 07:30T Cell Responsiveness in hCYP2D6-infected Mice
  • 08:15Conclusion

Summary

Traduction automatique

小鼠与表达人类的主要自身抗原的腺病毒感染的细胞色素P450 2D6(hCYP2D6)血清持久的特点是广泛的肝炎,肝纤维化和生成一种CYP2D6的形式在介导的自身免疫性肝病患者患有2型自身免疫性肝炎的结果确认特异性免疫反应。

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