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1Department of Physiology and Pharmacology,Loma Linda University School of Medicine, 2College of Natural and Agricultural Sciences,University of California, Riverside , 3Department of Anesthesiology,Loma Linda University School of Medicine, 4Department of Neurosurgery,Loma Linda University School of Medicine
Chapitres
- 00:00Titre
- 02:15Apparatus
- 03:00Presurgical Preparations
- 04:17ICH Surgery
- 07:39Behavioral Assessment
- 08:59Representative Results
Modelos animales clínicamente relevante de hemorragia intracerebral (HIC) son necesarios para profundizar en el conocimiento de accidente cerebrovascular hemorrágico y examinar nuevas estrategias terapéuticas. En este estudio, se describe y evaluar dos modelos que implementan ICH inyecciones unilaterales de sangre autóloga o bien total o colagenasa bacteriana en los ganglios basales (corpus striatum) de ratones.
Tags
ModelingIntracerebral HemorrhageMiceAutologous BloodBacterial CollagenasePreclinical ModelsTherapeutic StrategiesPathophysiologyHemorrhage InductionInjury ProgressionBlood Injection ModelCollagenase ModelBasal Lamina DisruptionPerihematomal EdemaNeurofunctional DeficitsDouble Injection ModelCD-1 MiceNeurofunctional DeficitsBrain Edema
