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Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants
 

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants

Article DOI: 10.3791/4379-v • 11:39 min • March 14th, 2013
March 14th, 2013 •
1, 1,2, 3, 1, 3, 4, 1, 3, 1
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 2Lab. PALM, Université de Caen Basse-Normandie, 3Fetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children's Hospital, Harvard Medical School, 4ISS, INC.

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We combined frequency-domain near-infrared spectroscopy measures of cerebral hemoglobin oxygenation with diffuse correlation spectroscopy measures of cerebral blood flow index to estimate an index of oxygen metabolism. We tested the utility of this measure as a bedside screening tool to evaluate the health and development of the newborn brain.

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Non-invasive Optical Measurement Cerebral Metabolism Hemodynamics Infants Perinatal Brain Injury Bedside Tool Brain Health CMRO2 Neuronal Viability Diagnostic Information Positron Emission Tomography (PET) Single-photon Emission Computed Tomography (SPECT) Radionucleotides Continuous-wave Near-infrared Spectroscopy (CWNIRS) Hemoglobin Oxygen Saturation (SO2) Surrogate Cerebral Oxygen Consumption Oxygen Delivery Brain Injury
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