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A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
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Journal JoVE Médecine
A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

DOI:
10.3791/50542-v

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05:51 min

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May 06, 2014

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, , , , , , , , ,
1Department of Cardiology,University of Heidelberg, 2Department of Vascular Surgery,University of Heidelberg, 3Department of Cardiology,SLK Hospital am Plattenwald

Chapitres

  • 00:05Titre
  • 01:45Plaque Processing
  • 03:16RNA Extraction from Cultured Plaque Pieces
  • 04:05Results: A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
  • 05:05Conclusion

Summary

Traduction automatique

Traduction automatique

Atherosclerosis is a chronic inflammatory process. This manuscript illustrates an easy to use ex vivo model to investigate fresh carotid or coronary artery plaques. The ex vivo model allows for the investigation of potential substances on the inflammatory milieu in human atherosclerotic lesions and results can be analyzed by various methods.

Tags

Keywords: AtherosclerosisEx VivoPlaque ModelLesion BiologyInflammatory ProcessesAtherogenesisHuman Immune SystemIn Vitro Cell ExperimentsCytokinesChemokinesImmunohistochemistryFlow CytometryELISA

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