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Chapitres
- 00:05Titre
- 01:39Phospho-protein Western Blot
- 03:02Methylcellulose Assay
- 04:24Evaluation of Phospho-protein Inhibition in vivo
- 05:39Evaluation of Anti-leukemia Activity of TKIs in ALL Xenograft Models
- 08:13Results: Biochemical and Functional Effects Mediated by TKIs
- 10:07Conclusion
Receptor tyrosine kinases are ectopically expressed in many cancers and have been identified as therapeutic targets in acute leukemia. This manuscript describes an efficient strategy for pre-clinical evaluation of tyrosine kinase inhibitors for the treatment of acute leukemia.
