JoVE Journal
Immunology and Infection
Immunology and Infection
Ce contenu est en libre accès.
Chapitres
résumé
Neisseria meningitidis is a human specific pathogen that infects blood vessels. In this protocol human microvessels are introduced into a mouse by grafting human skin onto immunocompromised mice. Bacteria adhere extensively to the human vessels, leading to vascular damage and development of the purpuric rash typically observed in human cases.