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Immunology and Infection

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JoVE Journal Immunology and Infection
Myelin Oligodendrocyte Glycoprotein (MOG35-55) Induced Experimental Autoimmune Encephalomyelitis (EAE) in C57BL/6 Mice
 

Myelin Oligodendrocyte Glycoprotein (MOG35-55) Induced Experimental Autoimmune Encephalomyelitis (EAE) in C57BL/6 Mice

Article DOI: 10.3791/51275-v • 08:03 min • April 15th, 2014
April 15th, 2014 •
1,2, 1, 1, 1,3
1Department of Neurology, University of Münster, 2Interdisciplinary Center for Clinical Research (IZKF), Münster, 3Institute of Physiology – Neuropathophysiology, University of Münster

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Experimental autoimmune encephalomyelitis (EAE) is an established animal model of multiple sclerosis. C57BL/6 mice are immunized with myelin oligodendrocyte glycoprotein (MOG) peptide 35-55 (MOG35-55), resulting in an ascending flaccid paralysis caused by autoreactive immune cells in the central nervous system. Protocols for disease induction and monitoring will be discussed.

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Myelin Oligodendrocyte Glycoprotein (MOG35-55) Experimental Autoimmune Encephalomyelitis (EAE) Multiple Sclerosis Neuroinflammatory Demyelinating Disorder Central Nervous System Autoreactive T Lymphocytes Pathophysiology MS Therapy Animal Model Clinical Features Immunological Aspects Histological Aspects Inducible Model Drugs Transgenic Mice Autoimmune Neuroinflammation CNS Homogenates Myelin Proteins Adjuvants EAE Susceptibility Phenotype
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