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A Murine Model of Myocardial Ischemia-reperfusion Injury through Ligation of the Left Anterior Descending Artery
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Médecine
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Journal JoVE Médecine
A Murine Model of Myocardial Ischemia-reperfusion Injury through Ligation of the Left Anterior Descending Artery

A Murine Model of Myocardial Ischemia-reperfusion Injury through Ligation of the Left Anterior Descending Artery

DOI:
10.3791/51329-v

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11:07 min

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April 10, 2014

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, , ,
1Davis Heart & Lung Research Institute, Department of Physiology and Cell Biology,The Ohio State University

Chapitres

  • 00:05Titre
  • 01:56Endotracheal Intubation
  • 04:00Thoracotomy
  • 05:29Left Anterior Descending Coronary Artery (LAD) Ligation and Reperfusion
  • 08:59Results: Representative Analysis of Murine Myocardial Ischemia-Reperfusion Injury
  • 10:05Conclusion

Summary

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Traduction automatique

We introduce a surgical method to induce experimental ischemia/reperfusion (I/R) injury to simulate myocardial infarction (MI) in mouse models that allows for more clarity in positioning of the ligation on the left anterior descending artery (LAD) to increase the reproducibility of MI experiments in mice.

Tags

Murine ModelMyocardial Ischemia-reperfusion InjuryLeft Anterior Descending Artery LigationMyocardial InfarctionSurgical MethodCardiovascularPathological MechanismsTherapeutic ApproachesPreclinical Testing

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