Journal
/
Chimie
/
Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
Journal JoVE
Chimie
Un abonnement à JoVE est nécessaire pour voir ce contenu.  Connectez-vous ou commencez votre essai gratuit.
Journal JoVE Chimie
Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography

DOI:
10.3791/51633-v

•

10:14 min

•

May 16, 2014

•

, ,
1Department of Chemistry,Imperial College London

Chapitres

  • 00:04Titre
  • 01:26Preparation of Iodoaziridines with Diiodomethyllithium
  • 04:32Assessment of Product Stability to Stationary Phases for Chromatography
  • 07:04Deactivation of Basic Alumina and Purification of the Iodoaziridine
  • 08:01Results: Diastereoselective Synthesis and Characterization of Iodoaziridines
  • 09:39Conclusion

Summary

Traduction automatique

Traduction automatique

A protocol for the diastereoselective one-pot preparation of cis-N-Ts-iodoaziridines is described. The generation of diiodomethyllithium, addition to N-Ts aldimines and cyclization of the amino gem-diiodide intermediate to iodoaziridines is demonstrated. Also included is a protocol to rapidly and quantitatively assess the most appropriate stationary phase for purification by chromatography.

Tags

IodoaziridinesDiiodomethyllithiumN-Ts AldiminesDiastereoselective SynthesisColumn ChromatographyStationary Phase SelectionQuantitative Analysis1H NMR SpectroscopyBasic AluminaSensitive Compounds

Article

Embed

AJOUTER À LA PLAYLIST

Usage Statistics

Vidéos Connexes

check_url/fr/51633?article_type=v

Determination of the Gas-phase Acidities of Oligopeptides
check_url/fr/51633?article_type=v

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
check_url/fr/51633?article_type=v

Quantitative Detection of Trace Explosive Vapors by Programmed Temperature Desorption Gas Chromatography-Electron Capture Detector
check_url/fr/51633?article_type=v

Supercritical Nitrogen Processing for the Purification of Reactive Porous Materials
check_url/fr/51633?article_type=v

A Quantitative Glycomics and Proteomics Combined Purification Strategy
check_url/fr/51633?article_type=v

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
check_url/fr/51633?article_type=v

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry
check_url/fr/51633?article_type=v

Facile Synthesis of Worm-like Micelles by Visible Light Mediated Dispersion Polymerization Using Photoredox Catalyst
check_url/fr/51633?article_type=v

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2′-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
check_url/fr/51633?article_type=v

Synthesis and Mass Spectrometry Analysis of Oligo-peptoids

Read Article