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Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
 

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography

Article DOI: 10.3791/51633-v • 10:14 min • May 16th, 2014
May 16th, 2014 •
1, 1, 1
1Department of Chemistry, Imperial College London

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Summary
Automatic Translation

A protocol for the diastereoselective one-pot preparation of cis-N-Ts-iodoaziridines is described. The generation of diiodomethyllithium, addition to N-Ts aldimines and cyclization of the amino gem-diiodide intermediate to iodoaziridines is demonstrated. Also included is a protocol to rapidly and quantitatively assess the most appropriate stationary phase for purification by chromatography.

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Keywords: Iodoaziridines Diiodomethyllithium N-Ts Aldimines Diastereoselective Synthesis Column Chromatography Stationary Phase Selection Quantitative Analysis 1H NMR Spectroscopy Basic Alumina Sensitive Compounds
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