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Journal / Medicine / Modeling Stroke in Mice: Permanent Coagulation of …
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Modeling Stroke in Mice
 

Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

Article DOI: 10.3791/51729-v • 08:14 min • July 31st, 2014
July 31st, 2014 •
*1,2, *1,2, 1,2, 3,4, 1,2
1Institute for Stroke and Dementia Research, University Hospital Munich, 2Munich Cluster for Systems Neurology (SyNergy), 3Department of Neurology, University Heidelberg, 4Imperial College, Charing Cross Hospital
* These authors contributed equally

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résumé
Automatic Translation

Various murine models of middle cerebral artery occlusion (MCAO) are widely used in experimental brain research. Here, we demonstrate the model of transcranial permanent distal MCAO which produces consistent cortical infarction of a size corresponding to damage imposed by the majority of human ischemic strokes.

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Keywords: Stroke Mouse Model Middle Cerebral Artery Coagulation Infarct Permanent Occlusion Cortex Reproducibility Low Mortality Pathophysiology Inflammation Angiogenesis Plasticity Regeneration Therapeutic Strategies
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