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La endotoxina intravenosa Challenge en seres humanos sanos: una plataforma experimental para investigar y modular la inflamación sistémica
Journal JoVE
Médecine
This content is Free Access.
Journal JoVE Médecine
Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
DOI:

07:48 min

May 16, 2016

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Chapitres

  • 00:05Titre
  • 01:19Endotoxin Challenge Participant Preparation
  • 03:35Endotoxin Administration and Monitoring
  • 05:40Results: Representative Cellular and Humoral Responses and Symptom Profile after CCRE Challenge
  • 06:36Conclusion

Summary

Traduction automatique

Intravenous administration of endotoxin reliably elicits dose-dependent physiological and immunological alterations consistent with several pathological states. This reductionist approach permits the investigation, modeling and experimental modification of systemic inflammation and its downstream effects in man.

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