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Bioengineering

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TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application

Article DOI: 10.3791/53930-v • 08:40 min • June 8th, 2016
June 8th, 2016 •
1, 1,2, 2,3
1The Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology (KAIST), 2Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), 3Center for Systems Biology, Massachusetts General Hospital/Harvard Medical School

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résumé
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We describe the simplest protocol to prepare biodegradable medical glue that has an effective hemostatic ability. TAPE is a water-immiscible supramolecular aggregate prepared by mixing of tannic acid, a ubiquitous compound found in plants, and poly(ethylene) glycol, yielding a 2.5 times greater water-resistant adhesion compared with commercial fibrin glue.

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Keywords: TAPE Biodegradable Hemostatic Glue Surgical Application Tannic Acid PEG Adhesive Strength Tissue Adhesive Sealant Porcine Biopsy Skin Cyanoacrylate Glue Force-distance Curve Water Resistance
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