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JoVE Journal Bioengineering
Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes
 

Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes

Article DOI: 10.3791/54106-v • 10:33 min • July 23rd, 2016
July 23rd, 2016 •
1, 1, 1
1Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University

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The goal of this protocol is to use cationic/anionic liposomes with a neuro-targeting peptide as a CNS delivery system to enable siRNA to cross the BBB. The optimization of a delivery system for treatments, like siRNA, would allow for more treatment options for prion and other neurodegenerative diseases.

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Keywords: SiRNA Delivery Liposomal Drug Delivery Blood-brain Barrier Neurodegenerative Diseases DOTAP Cholesterol Liposome Preparation Extrusion RVG-9R Targeting Peptide
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