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जीर्ण Amyloid-बीटा Oligomer निषेचन के एक पशु मॉडल में Neurodegeneration आसमाटिक पंप के साथ एंटीबॉडी उपचार संचार द्वारा counteracted है
Journal JoVE
Médecine
This content is Free Access.
Journal JoVE Médecine
Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps
DOI:

10:19 min

August 14, 2016

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Chapitres

  • 00:05Titre
  • 00:51Implantation of Cannula
  • 04:32Osmotic Pump Installation
  • 05:47Aβo Infusion in Awake and Freely Moving Rats
  • 08:43Results: Neuronal Loss Induced by Aβo Deposition is Attenuated by 6E10 Antibody Treatment
  • 09:23Conclusion

Summary

Traduction automatique

To study the effects of Aβo in vivo, we developed a model based on repeated hippocampal infusions of soluble Aβo coupled with continuous infusion of Aβo antibody (6E10) in the hippocampus using osmotic pumps to counteract the neurotoxic effect of Aβo.

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