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Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps
 

Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps

Article DOI: 10.3791/54215-v • 10:19 min • August 14th, 2016
August 14th, 2016 •
1,3, 3, 2, 1,3
1Department of Pharmacology, Université de Montréal, 2Department of Neuroscience, Université de Montréal, 3Hôpital du Sacré-coeur de Montréal Research Center, Université de Montréal

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résumé
Automatic Translation

To study the effects of Aβo in vivo, we developed a model based on repeated hippocampal infusions of soluble Aβo coupled with continuous infusion of Aβo antibody (6E10) in the hippocampus using osmotic pumps to counteract the neurotoxic effect of Aβo.

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Keywords: Amyloid-beta Oligomer Neurodegeneration Alzheimer's Disease Animal Model Antibody Treatment Osmotic Pumps Cannula Implantation Stereotaxic Frame Neurotoxicity Immunotherapy
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