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Bioengineering

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JoVE Journal Bioengineering
Modeling Ovarian Cancer Multicellular Spheroid Behavior in a Dynamic 3D Peritoneal Microdevice
 

Modeling Ovarian Cancer Multicellular Spheroid Behavior in a Dynamic 3D Peritoneal Microdevice

Article DOI: 10.3791/55337-v • 11:34 min • February 18th, 2017
February 18th, 2017 •
*1, *1, *2, 2, 3, 3, 4, 2, 1
1School of Biological Sciences, University of Hong Kong, 2Department of Mechanical Engineering, University of Hong Kong, 3Department of Medicine, University of Hong Kong, 4Department of Biomedical Sciences, Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institutes of City University of Hong Kong
* These authors contributed equally

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résumé
Automatic Translation

To study ovarian tumor progression in a physiologically relevant model, multicellular spheroids were cultured in a microdevice under simulated fluid flow. This dynamic 3D model emulates the intraperitoneal environment with the cellular and mechanical components where ovarian cancer metastasis occurs.

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Keywords: Ovarian Cancer Multicellular Spheroid 3D Microdevice Peritoneal Microenvironment Metastasis Co-culture Microfluidics SU-8 Photoresist PDMS Microfabrication
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