Creation of Cardiac Tissue Exhibiting Mechanical Integration of Spheroids Using 3D Bioprinting

Chin Siang Ong; Takuma Fukunishi; Andrew Nashed; Adriana Blazeski; Huaitao Zhang; Samantha Hardy; Deborah DiSilvestre; Luca Vricella; John Conte; Leslie Tung; Gordon Tomaselli; Narutoshi Hibino

doi:10.3791/55438

Journal

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Bio-ingénierie

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Creation of Cardiac Tissue Exhibiting Mechanical Integration of Spheroids Using 3D Bioprinting

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Bio-ingénierie
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Journal JoVE Bio-ingénierie

Creation of Cardiac Tissue Exhibiting Mechanical Integration of Spheroids Using 3D Bioprinting

DOI:

10.3791/55438-v

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04:40 min

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July 02, 2017

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Chin Siang Ong², Takuma Fukunishi, Andrew Nashed, Adriana Blazeski, Huaitao Zhang, Samantha Hardy, Deborah DiSilvestre, Luca Vricella, John Conte, Leslie Tung, Gordon Tomaselli, Narutoshi Hibino

¹Division of Cardiac Surgery,Johns Hopkins Hospital, ²Division of Cardiology,Johns Hopkins Hospital, ³Department of Biomedical Engineering,Johns Hopkins University

Chapitres

00:05Titre
00:593D Bioprinting of Spheroids
02:16Removal of Patch from the Needle Array and Patch Maturation
03:35Results: 3D Bioprinted Spheroids Exhibit Mechanical Integration
03:55Conclusion

Summary

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This protocol describes 3D bioprinting of cardiac tissue without the use of biomaterials. 3D bioprinted cardiac patches exhibit mechanical integration of component spheroids and are highly promising in cardiac tissue regeneration and as 3D models of heart disease.

Creation of Cardiac Tissue Exhibiting Mechanical Integration of Spheroids Using 3D Bioprinting

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Chapitres

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