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Induktion og Micro-CT billeddannelse af Cerebral bundløs misdannelser i musen Model
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JoVE Journal Medicine
Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model

Induktion og Micro-CT billeddannelse af Cerebral bundløs misdannelser i musen Model

DOI:
10.3791/56476-v

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05:12 min

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September 04, 2017

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, , , ,
1Lab of Cardiovascular Signaling,Centenary Institute, 2Faculty of Medicine, Sydney Medical School,University of Sydney, 3Department of Pharmacology, School of Basic Medical Sciences,Tianjin Medical University, 4Australian Centre for Microscopy & Microanalysis,University of Sydney

Chapters

  • 00:05Title
  • 00:57Induction of Cerebral Cavernous Malformations in Mouse Models
  • 01:38Sample Preparation for Micro-CT Scans
  • 03:15Micro-CT Scan of CCM in the Neonatal Mouse Brain
  • 03:57Results: Rendered 3-D Images Showing CCM Lesions in the Neonatal Mouse
  • 04:34Conclusion

Summary

Automatic Translation

Automatic Translation

Denne protokol viser induktion af cerebral bundløs misdannelser sygdom i en musemodel og bruger kontrast forbedret mikro computertomografi for at måle læsion byrde. Denne metode øger værdien af etablerede musemodeller at studere det molekylære grundlag og potentielle terapier for cerebral bundløs misdannelser og andre cerebrovaskulære sygdomme.

Tags

Cerebral Cavernous MalformationsNeonatal MiceMicro-CT Imaging4-HTParaformaldehydeLugol’s IodineBrain ImagingVascular Disease

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