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The Pilocarpine Model of Temporal Lobe Epilepsy and EEG Monitoring Using Radiotelemetry System in Mice
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Journal JoVE Médecine
The Pilocarpine Model of Temporal Lobe Epilepsy and EEG Monitoring Using Radiotelemetry System in Mice

The Pilocarpine Model of Temporal Lobe Epilepsy and EEG Monitoring Using Radiotelemetry System in Mice

DOI:
10.3791/56831-v

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10:08 min

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February 27, 2018

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,
1Department of Pharmacology, Catholic Neuroscience Institute, College of Medicine,The Catholic University of Korea

Chapitres

  • 00:04Titre
  • 00:50Status Epilepticus (SE) Induction
  • 03:24Implantation Surgery for Video-EEG Monitoriing
  • 06:19Video and EEG Monitoring and Analysis
  • 08:01Results: Successful SE Can Induce Hippocampal Cell Death and SRS
  • 09:03Conclusion

Summary

Traduction automatique

Traduction automatique

This manuscript describes a method of inducing status epilepticus by systemic pilocarpine injection and of monitoring spontaneous recurrent seizures in live animals using a wireless telemetry video and electroencephalogram system. This protocol can be utilized for studying the pathophysiologic mechanisms of chronic epilepsy, epileptogenesis, and acute seizures.

Tags

PilocarpineTemporal Lobe EpilepsyEEG MonitoringRadiotelemetryMiceStatus EpilepticusEpileptogenesisChronic EpilepsyScopolamineTerbutalineDiazepamTelemetry ImplantationEEG

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