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Systematic Assessment of Well-Being in Mice for Procedures Using General Anesthesia
 

Systematic Assessment of Well-Being in Mice for Procedures Using General Anesthesia

Article DOI: 10.3791/57046-v • 06:50 min • March 20th, 2018
March 20th, 2018 •
1,2, 2,3, 2, 4, 2, 1
1Institute of Animal Welfare, Animal Behavior and Laboratory Animal Science, Department of Veterinary Medicine, Freie Universität Berlin, 2Institute of Pharmacology and Toxicology, Department of Veterinary Medicine, Freie Universität Berlin, 3German Federal Institute for Risk Assessment (BfR), 4Unit of Physiology, Pathophysiology and Experimental Endocrinology, Department of Biomedical Sciences, University of Veterinary Medicine

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We developed a protocol to assess well-being in mice during procedures using general anesthesia. A series of behavioral parameters indicating levels of well-being as well as glucocorticoid metabolites were analyzed. The protocol can serve as a general aid to estimate the degree of severity in a scientific, animal-centered manner.

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Systematic Assessment Well-being Mice Procedures General Anesthesia Scientific Data Severity Classification EU Directive Animal Welfare Laboratory Animal Science Distress Protocol Adaptation Integration Repeated Anesthesia Stress Glass Box Bedding Material Food And Water Observation Cage Habituate Mouse Grimace Scale High-definition Camera
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