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Assessing Neuroprotective Effects of Glycyrrhizae Radix et Rhizoma Extract Using a Transient Middle Cerebral Artery Occlusion Mouse Model
 

Assessing Neuroprotective Effects of Glycyrrhizae Radix et Rhizoma Extract Using a Transient Middle Cerebral Artery Occlusion Mouse Model

Article DOI: 10.3791/58454-v • 08:53 min • December 9th, 2018
December 9th, 2018 •
*1, *2, 1, 2, 1, 3, 1
1School of Korean Medicine, Pusan National University, 2College of Medicine, Dongguk University, 3Kyunghee Naseul Korean Medicine Clinic
* These authors contributed equally

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In this study, we modify an existing experimental method to obtain more reproducible results, by establishing a middle cerebral artery occlusion (MCAO) mouse model. Oral administration of Glycyrrhizae Radix et Rhizome (GR) methanol extract (GRex), following stroke induction, significantly decreased total infarction volume relative to the untreated control group.

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Glycyrrhizae Radix Et Rhizoma Extract Neuroprotective Effects Transient Middle Cerebral Artery Occlusion Mouse Model Neuroscience Research Oral Medicine Research Screening Neuroprotective Compounds Ischemic Timing Dose Sterile Microscope Se-Eun Lee GRex Preparation Methanol Incubation Filtration Process Freeze-drying GRex Administration Dimethylsulfoxide Physiological Saline
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