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Undertrykkelse af myelomatose cellevækst In Vivo af enkelt-væg kulstof nanorør (SWCNT)-leveres MALAT1 Antisense Oligos
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Chapters
- 00:04Title
- 00:56Synthesis of Functionalized SWCNTs
- 01:53Conjugation of Anti-MALAT1 Gapmer DNA Flanked by 2′-O Modified RNAs to Functionalized SWCNT
- 02:54Tail Vein Injection of SWCNT-anti-MALAT1
- 04:14Evaluation of the Disease Progression
- 05:01Results: SWCNT-anti-MALAT1 Oligonucleotides Successfully Represses Multiple Myeloma Cell Growth
- 06:51Conclusion
Dette manuskript beskriver syntesen af en enkelt-væg kulstof nanorør (SWCNT)-konjugeret MALAT1 antisense gapmer DNA oligonukleotid (SWCNT-anti-MALAT1), som viser den pålidelig levering af SWCNT og den potent terapeutiske effekt af anti-MALAT1 in vitro og in vivo. Metoder anvendes til syntese, ændring, konjugering, og injektion af SWCNT-anti-MALAT1 er beskrevet.
