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Cancer Research

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JoVE Journal Cancer Research
An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
 

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Article DOI: 10.3791/59368-v • 06:38 min • September 12th, 2019
September 12th, 2019 •
*1,2,3, *1,2, 1,2, 1,2, 1,2, 1,2, 1,2,3
1Department of Surgery, University of Missouri-Columbia, 2Ellis Fischel Cancer Center, University of Missouri-Columbia, 3Molecular Microbiology and Immunology, University of Missouri-Columbia
* These authors contributed equally

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résumé
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Here, we describe the development of a clinically relevant murine model of liver cancer recapitulating the typical immune features of hepatocellular cancer (HCC).

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Keywords: Hepatocellular Cancer Orthotopic Mouse Model Hepatic Inflammation Fibrosis Tumor Immunology Tumor Microenvironment Liver Cancer Tumor Perfusion Collagenase Digestion Tumor Implantation
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