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Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
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Médecine
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Journal JoVE Médecine
Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

DOI:
10.3791/60036-v

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07:26 min

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July 14, 2021

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, , ,
1Unidade de Investigação Cardiovascular, Departamento de Cirurgia e Fisiologia, Faculdade de Medicina,Universidade do Porto

Chapitres

  • 00:04Introduction
  • 01:07Aortic Banding Preparation and Post-Operative Care
  • 02:40Aortic Debanding
  • 03:36Echocardiography (ECG)
  • 05:26Results: Representative Echocardiographic, Pressure Volume, and Histological Assessments of Cardiac Structure and Function
  • 06:38Conclusion

Summary

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Here we describe a step-by-step protocol of surgical aorta debanding in the well-established mice model of aortic-constriction. This procedure not only allows studying the mechanisms underlying the left ventricular reverse remodeling and regression of hypertrophy but also to test novel therapeutic options that might accelerate myocardial recovery.

Tags

Left Ventricular Reverse RemodelingAortic DebandingRodentsMyocardial Reverse RemodelingCardiomyocytes RegressionIsometric Functional RecoveryPressure OverloadAortic StenosisMechanical VentilationAnalgesiaAortic BandingAortic Debanding

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