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A Reversible Silicon Oil-Induced Ocular Hypertension Model in Mice
 

A Reversible Silicon Oil-Induced Ocular Hypertension Model in Mice

Article DOI: 10.3791/60409-v • 09:03 min • November 15th, 2019
November 15th, 2019 •
1,2, 1,3, 1, 1, 1, 1,4, 1,4, 1
1Department of Ophthalmology, Stanford University School of Medicine, 2Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 3Department of Ophthalmology, Second Xiangya Hospital of Central South University, 4Department of Ophthalmology, Veterans Affairs Palo Alto Health Care

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Here, we present a protocol to induce ocular hypertension and glaucomatous neurodegeneration in mouse eyes by intracameral injection of silicone oil and the procedure for silicone oil removal from the anterior chamber to return elevated intraocular pressure to normal.

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Reversible Silicon Oil-induced Ocular Hypertension Model Glaucoma Retinal Ganglion Cell Death Opto-neurodegeneration Intraocular Pressure Ocular Hypertension Model Experimental Animals Mice Neurodegeneration Treatment For Neuroprotection Secondary Glaucoma Pupilar Blocking IOP Elevation Silicone Oil Removal Glass Micropipette Intracameral Silicone Oil Injection
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