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Bioengineering

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JoVE Journal Bioengineering
Design of a Biocompatible Drug-Eluting Tracheal Stent in Mice with Laryngotracheal Stenosis
 

Design of a Biocompatible Drug-Eluting Tracheal Stent in Mice with Laryngotracheal Stenosis

Article DOI: 10.3791/60483-v • 08:26 min • January 21st, 2020
January 21st, 2020 •
1, 2, 2, 2, 2, 2, 2
1Department of General Surgery, University of California, San Francisco, 2Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine

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Automatic Translation

Laryngotracheal stenosis results from pathologic scar deposition that critically narrows the tracheal airway and lacks effective medical therapies. Using a PLLA-PCL (70% poly-L-lactide and 30% polycaprolactone) stent as a local drug delivery system, potential therapies aimed at decreasing scar proliferation in the trachea can be studied.

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Keywords: Biocompatible Drug-eluting Tracheal Stent Laryngotracheal Stenosis Mouse Model Transoral Intubation Rapamycin PLLA-PCL Angiocatheter Stent Casting Preclinical Investigation Translational Research
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