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JoVE Journal Behavior
Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
 

Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats

Article DOI: 10.3791/60562-v • 07:12 min • January 21st, 2020
January 21st, 2020 •
*1, *1, 1, 1, 2, 1, 1, 1
1Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, 2Academy of Chinese Medical Sciences, Zhejiang Chinese Medical University
* These authors contributed equally

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résumé
Automatic Translation

Provided here is a protocol that details steps to establish an animal model of chronic post-ischemia pain (CPIP). This is a well-recognized model mimicking human complex regional pain syndrome type-I. Mechanical and thermal hypersensitivities are further evaluated, as well as capsaicin-induced nocifensive behaviors observed in the CPIP rat model.

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Chronic Post-Ischemia Pain Model Complex Regional Pain Syndrome Type-I CRPS I Rats Preclinical Animal Model CRPS I Mechanisms Rat CPIP Model Hindlimb Edema Hyperemia Thermal Hypersensitivity Mechanical Hypersensitivity Anesthetizing Rats Sodium Phenobarbital Pinching Hind Paw Or Tail Vet Ointment On Eyes Heated Pad Lubricating Hind Paw And Ankle With Glycerol Nitrile O Ring Ischemia Induction Sham Group Of Rats Broken O Ring Monitoring Rat Recovery From Anesthesia
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