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JoVE Journal Bioengineering
Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons
 

Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons

Article DOI: 10.3791/62013-v • 09:54 min • July 14th, 2021
July 14th, 2021 •
1,4, 2,4, 2,4, 1,4, 2,4, 2,4, 3,4, 2,4, 1,4
1Department of Physics, Bar-Ilan University, 2Faculty of Engineering, Bar-Ilan University, 3Department of chemistry, Bar-Ilan University, 4The Institutes of Nanotechnology & Advanced Materials, Bar-Ilan University

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résumé
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This work presents a bottom-up approach to the engineering of local magnetic forces for control of neuronal organization. Neuron-like cells loaded with magnetic nanoparticles (MNPs) are plated atop and controlled by a micro-patterned platform with perpendicular magnetization. Also described are magnetic characterization, MNP cellular uptake, cell viability, and statistical analysis.

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Magnetic Platforms Micron-scale Organization Interconnected Neurons Neural Network Formation Magnetic Manipulations In Vitro Studies Biointerfacing Devices Magnetic Nanoparticles Steriloptic Size Coating Magnetization Value Glass Slides Acetone Isopropanol Ultrasonication Bath Photoresist Spin Coating Lithography Developer Distilled Water
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