Waiting
Traitement de la connexion…

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Cancer Research / Portal Vein Injection of Colorectal Cancer…
JoVE Journal
Cancer Research

Un abonnement à JoVE est nécessaire pour afficher ce contenu. Connectez-vous ou commencez votre essai gratuit.

JoVE Journal Cancer Research
Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma
 

Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma

Article DOI: 10.3791/62630-v • 07:59 min • September 3rd, 2021
September 3rd, 2021 •
1,2,3,4, 1,2, 1,2, 1,2, 1,2, 1,2, 1,2, 1,2, 1,2,5, 1,2, 2, 1,2, 6, 3,4,7, 3, 2, 1,2
1Adelaide Medical School, University of Adelaide, 2South Australian Health and Medical Research Institute (SAHMRI), 3Department of Pathology, Nagoya University Graduate School of Medicine, 4Division of Molecular Pathology, Center for Neurological Disease and Cancer, Nagoya University Graduate School of Medicine, 5Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 6Translational and Clinical Research Institute, Newcastle University, 7International Center for Cell and Gene Therapy, Fujita Health University

Chapitres

résumé
Automatic Translation

Portal vein injection of colorectal cancer (CRC) organoids generates stroma-rich liver metastasis. This mouse model of CRC hepatic metastasis represents a useful tool to study tumor-stroma interactions and develop novel stroma-directed therapeutics such as adeno-associated virus-mediated gene therapies.

Tags

Keywords: Portal Vein Colorectal Cancer Liver Metastasis Tumor Stroma Organoids Tumoroids CAS Tumor Microenvironment Mouse Model Surgical Procedure Buprenorphine Anesthesia Incision Peritoneum
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter