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JoVE Journal Neuroscience
Measuring Contralateral Silent Period Induced by Single-Pulse Transcranial Magnetic Stimulation to Investigate M1 Corticospinal Inhibition
 

Measuring Contralateral Silent Period Induced by Single-Pulse Transcranial Magnetic Stimulation to Investigate M1 Corticospinal Inhibition

Article DOI: 10.3791/64231-v • 07:33 min • August 23rd, 2022
August 23rd, 2022 •
1, 1, 1,2, 1, 1, 1, 1, 1, 1, 3, 3,4, 1
1Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, 2Universidad de Investigación para la Generación y Síntesis de Evidencia en Salud, Universidad San Ignacio de Loyola, 3Research and Development, Soterix Medical, 4City College of New York

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Contralateral silent period (cSP) assessment is a promising biomarker to index cortical excitability and treatment response. We demonstrate a protocol to assess cSP intended for studying M1 corticospinal inhibition of upper and lower limbs.

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Contralateral Silent Period Single-pulse Transcranial Magnetic Stimulation M1 Corticospinal Inhibition Upper Limb Assessment Lower Limb Assessment Neurological Diseases Diagnostic Biomarker Surrogate Biomarker Predictive Biomarker Muscle Positioning First Dorsal Interosseous (FDI) Muscle Alcohol Pads Impedance Negative Electrode Positive Electrode Interelectrode Distance Reference Electrode Ulnar Styloid Process Muscle Contraction Force Digital Pinch Dynamometer
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