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网络药理学预测及代谢组学验证凤仙花抗高脂血症的机制

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Médecine

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Journal JoVE Médecine

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

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网络药理学预测及代谢组学验证凤仙花抗高脂血症的机制

DOI:

10.3791/65071-v

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11:06 min

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April 07, 2023

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Baihan Zeng*^1,2,3, Luming Qi*^1,2,3, Sha Wu*^1,2,3, Nannan Liu^2,3, Jie Wang^2,3, Kaidi Nie^2,3, Lina Xia^2,3, Shuguang Yu³

¹School of Health Preservation and Rehabilitation,Chengdu University of Traditional Chinese Medicine, ²State Administration of Traditional Chinese Medicine Key Laboratory of Traditional Chinese Medicine, Regimen and Health,Chengdu University of Traditional Chinese Medicine, ³Key Laboratory of Traditional Chinese Medicine Regimen and Health of Sichuan Province

Chapitres

00:04Introduction
00:52Network Pharmacology-Based Prediction
04:52Metabolomic Validation
06:03Molecular Docking
08:11Results: Network Pharmacology Prediction and Metabolomics Validation
10:36Conclusion

Summary

Traduction automatique

本协议描述了一种基于网络药理学预测和代谢组学验证的探索叶藻对抗高脂血症的关键靶点和机制的综合策略。

Tags

Keywords: Network Pharmacology Metabolomics Fructus Phyllanthi Hyperlipidemia Active Ingredients Key Targets Protein-protein Interaction Network Drug-component-disease Target Network Hub Genes Traditional Chinese Medicine Systems Pharmacology

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