Ambika Goel Bajpayee Department of Bioengineering Northeastern University Biography Publications Institution JoVE Articles Ambika Goel BajpayeeAssistant Professor Ambika Bajpayee is an Assistant Professor in the Department of Bioengineering at Northeastern University and heads the Molecular Bioelectrostatics and Drug Delivery Lab. Her interests include targeted drug delivery, bio-electrostatics, cell derived exosomes, peptide and protein-based nanocarriers, and modeling of bio-transport and biomechanics. Ambika received her PhD in Mechanical Engineering at Massachusetts Institute of Technology (MIT) and also completed her post-doctoral work there focused on developing devices for oral drug delivery to the gastrointestinal tract and investigating disease-related changes in mechanics and permeability of mucosal membranes. Previously, she worked as a medical device engineer on development and FDA approval of orthopedic and dental implants. Ambika is a recipient of the US Department of Defense Discovery Award, National Institute of Health Trailblazer Award, MIT Women of Excellence and Meredith Kamm Memorial Award in Mechanical Engineering. Her laboratory is also funded by other NIH translational awards and the pharmaceutical industry, and works towards bridging the gap between basic science and clinical technologies. She holds a Masters degree from MIT and an undergraduate degree from the University of Delhi, India. Outside of the lab, Ambika loves to spend time with her one-year old new boss, oil paint, play chess, cook and travel to faraway lands. Publications Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers Journal of Visualized Experiments. 2020 | Pubmed ID: Avidin grafted dextran nanostructure enables a month-long intra-discal retention Scientific Reports. 2020 | Pubmed ID: Overcoming negatively charged tissue barriers: Drug delivery using cationic peptides and proteins Nano Today. 2020 | Pubmed ID: Bioelectricity for Drug Delivery: The Promise of Cationic Therapeutics Bioelectricity. 2020 | Pubmed ID: Avidin-biotin technology to synthesize multi-arm nano-construct for drug delivery MethodsX. 2020 | Pubmed ID: Multi-arm Avidin nano-construct for intra-cartilage delivery of small molecule drugs Journal of Controlled Release. 2019 | Pubmed ID: Interleukin-1 receptor antagonist (IL-1Ra) is more effective in suppressing cytokine induced catabolism in cartilage-synovium co-culture than cartilage monoculture Arthritis Research Therapy. 2019 | Pubmed ID: Cartilage penetrating cationic peptide carriers for applications in drug delivery to avascular negatively charged tissues. Acta Biomaterialia. 2019 | Pubmed ID: A once-a-month oral contraceptive Science Translation Medicine. 2019 | Pubmed ID: Scalable Gastric Resident Systems for Veterinary Applications Scientific Reports. 2018 | Pubmed ID: Multi-scale imaging techniques to investigate solute transport across articular cartilage Journal of Biomechanics. 2018 | Pubmed ID: Sustained intra-cartilage delivery of low dose dexamethasone using a cationic carrier for treatment of post traumatic osteoarthritis European Cell & Materials. 2017 | Pubmed ID: Cartilage Targeting Drug Delivery: Can Electrostatic Interactions Help? Nature Rheumatology Reviews. 2017 | Pubmed ID: Charge Based Intra-cartilage Delivery of Single Dose Dexamethasone Using Avidin Nano-carriers Suppresses Cytokine-induced Catabolism Long Term Osteoarthritis & Cartilage. 2016 | Pubmed ID: Drug Delivery to Chondrocytes Osteoarthritis & Cartilage. 2016 | Pubmed ID: A Rabbit Model Demonstrates the Influence of Cartilage Thickness on Intra-articular Drug Delivery and Retention within Cartilage Journal of Orthopaedic Research. 2015 | Pubmed ID: Electrostatic Interactions Enable Rapid Penetration, Enhanced Uptake and Retention of Intra-articular Injected Avidin in Rat Knee Joints Journal of Orthopaedic Research. 2014 | Pubmed ID: Avidin as a Model for Charge Driven Transport into Cartilage and Drug Delivery for Treating Early Stage PTOA Biomaterials. 2014 | Pubmed ID: Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers Armin Vedadghavami1, Shikhar Mehta1, Ambika G. Bajpayee1,2 1Department of Bioengineering, Northeastern University, 2Department of Mechanical & Industrial Engineering, Northeastern University JoVE 61340 Bioingegneria
Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers Armin Vedadghavami1, Shikhar Mehta1, Ambika G. Bajpayee1,2 1Department of Bioengineering, Northeastern University, 2Department of Mechanical & Industrial Engineering, Northeastern University JoVE 61340 Bioingegneria