Amy S. Gladfelter Department of Biochemistry and Biophysics University of North Carolina at Chapel Hill Biography Publications Institution JoVE Articles Amy S. Gladfelter has not added a biography. If you are Amy S. Gladfelter and would like to personalize this page please email our Author Liaison for assistance. Publications PRD-2 Mediates Clock-regulated Perinuclear Localization of Clock Gene RNAs Within the Circadian Cycle of Proceedings of the National Academy of Sciences of the United States of America. Aug, 2022 | Pubmed ID: 35881801 Double-stranded RNA Drives SARS-CoV-2 Nucleocapsid Protein to Undergo Phase Separation at Specific Temperatures Nucleic Acids Research. Jul, 2022 | Pubmed ID: 35871289 Membrane Surfaces Regulate Assembly of Ribonucleoprotein Condensates Nature Cell Biology. 04, 2022 | Pubmed ID: 35411085 Dilute Phase Oligomerization Can Oppose Phase Separation and Modulate Material Properties of a Ribonucleoprotein Condensate Proceedings of the National Academy of Sciences of the United States of America. 03, 2022 | Pubmed ID: 35333653 Design Considerations for Analyzing Protein Translation Regulation by Condensates RNA (New York, N.Y.). 01, 2022 | Pubmed ID: 34670845 Getting Droplets into Shape Science (New York, N.Y.). Sep, 2021 | Pubmed ID: 34516805 Evolution and Physiology of Amphibious Yeasts Annual Review of Microbiology. 10, 2021 | Pubmed ID: 34351793 Role of Spatial Patterning of N-protein Interactions in SARS-CoV-2 Genome Packaging Biophysical Journal. 07, 2021 | Pubmed ID: 34214535 Moving Beyond Disease to Function: Physiological Roles for Polyglutamine-rich Sequences in Cell Decisions Current Opinion in Cell Biology. 04, 2021 | Pubmed ID: 33610098 Role of Spatial Patterning of N-protein Interactions in SARS-CoV-2 Genome Packaging BioRxiv : the Preprint Server for Biology. Apr, 2021 | Pubmed ID: 33442696 HSP70 Chaperones RNA-free TDP-43 into Anisotropic Intranuclear Liquid Spherical Shells Science (New York, N.Y.). 02, 2021 | Pubmed ID: 33335017 The State of the Septin Cytoskeleton from Assembly to Function Current Opinion in Cell Biology. 02, 2021 | Pubmed ID: 33188984 RNA Contributions to the Form and Function of Biomolecular Condensates Nature Reviews. Molecular Cell Biology. 03, 2021 | Pubmed ID: 32632317 Shed Light in the DaRk LineagES of the Fungal Tree of Life-STRES Life (Basel, Switzerland). Dec, 2020 | Pubmed ID: 33352712 Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid Molecular Cell. 12, 2020 | Pubmed ID: 33290746 Modeling the Mechanisms by Which Coexisting Biomolecular RNA-Protein Condensates Form Bulletin of Mathematical Biology. 11, 2020 | Pubmed ID: 33231755 Specific Viral RNA Drives the SARS CoV-2 Nucleocapsid to Phase Separate BioRxiv : the Preprint Server for Biology. Jun, 2020 | Pubmed ID: 32587965 Spatial Heterogeneity of the Cytosol Revealed by Machine Learning-based 3D Particle Tracking Molecular Biology of the Cell. 07, 2020 | Pubmed ID: 32401664 Phosphoregulation Provides Specificity to Biomolecular Condensates in the Cell Cycle and Cell Polarity The Journal of Cell Biology. 07, 2020 | Pubmed ID: 32399546 FXR1 Splicing is Important for Muscle Development and Biomolecular Condensates in Muscle Cells The Journal of Cell Biology. 04, 2020 | Pubmed ID: 32328638 Unconventional Cell Division Cycles from Marine-Derived Yeasts Current Biology : CB. 10, 2019 | Pubmed ID: 31607535 The Control Centers of Biomolecular Phase Separation: How Membrane Surfaces, PTMs, and Active Processes Regulate Condensation Molecular Cell. 10, 2019 | Pubmed ID: 31604601 Marine Fungi Current Biology : CB. 03, 2019 | Pubmed ID: 30889385 Fungi in the Marine Environment: Open Questions and Unsolved Problems MBio. 03, 2019 | Pubmed ID: 30837337 Partial Demixing of RNA-protein Complexes Leads to Intradroplet Patterning in Phase-separated Biological Condensates Physical Review. E. Jan, 2019 | Pubmed ID: 30780260 Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors Neuron. 03, 2019 | Pubmed ID: 30713029 Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates Cell. 01, 2019 | Pubmed ID: 30682370 An Amphipathic Helix Enables Septins to Sense Micrometer-scale Membrane Curvature The Journal of Cell Biology. 04, 2019 | Pubmed ID: 30659102 Probing RNA Structure in Liquid-Liquid Phase Separation Using SHAPE-MaP Methods in Enzymology. 2018 | Pubmed ID: 30471703 A New Lens for RNA Localization: Liquid-Liquid Phase Separation Annual Review of Microbiology. Sep, 2018 | Pubmed ID: 30200855 MRNA Structure Determines Specificity of a PolyQ-driven Phase Separation Science (New York, N.Y.). 05, 2018 | Pubmed ID: 29650703 LITE Microscopy: Tilted Light-sheet Excitation of Model Organisms Offers High Resolution and Low Photobleaching The Journal of Cell Biology. 05, 2018 | Pubmed ID: 29490939 Control of Septin Filament Flexibility and Bundling by Subunit Composition and Nucleotide Interactions Molecular Biology of the Cell. 03, 2018 | Pubmed ID: 29321251 The Unsolved Problem of How Cells Sense Micron-Scale Curvature Trends in Biochemical Sciences. 12, 2017 | Pubmed ID: 29089160 Lessons from Yeast on How to Avoid Stress Eating Developmental Cell. 10, 2017 | Pubmed ID: 29017028 What Your PI Forgot to Tell You: Why You Actually Might Want a Job Running a Research Lab Molecular Biology of the Cell. Jul, 2017 | Pubmed ID: 28663288 Dissection of Molecular Assembly Dynamics by Tracking Orientation and Position of Single Molecules in Live Cells Proceedings of the National Academy of Sciences of the United States of America. 10, 2016 | Pubmed ID: 27679846 Yeast Cdc42 Functions at a Late Step in Exocytosis, Specifically During Polarized Growth of the Emerging Bud The Journal of Cell Biology. Nov, 2001 | Pubmed ID: 11706050 Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions Brandy N. Curtis*1, Ellysa J. D. Vogt*2, Kevin S. Cannon1,3, Amy S. Gladfelter1,2,3 1Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, 2Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, 3Department of Biology, University of North Carolina at Chapel Hill JoVE 64090 Biochimica
Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions Brandy N. Curtis*1, Ellysa J. D. Vogt*2, Kevin S. Cannon1,3, Amy S. Gladfelter1,2,3 1Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, 2Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, 3Department of Biology, University of North Carolina at Chapel Hill JoVE 64090 Biochimica