Arcadi Navarro IBE, Institute of Evolutionary Biology (UPF-CSIC), Department of Medicine and Life Sciences Universitat Pompeu Fabra Biography Publications Institution JoVE Articles Arcadi Navarro has not added a biography. If you are Arcadi Navarro and would like to personalize this page please email our Author Liaison for assistance. Publications Identification of Constrained Sequence Elements Across 239 Primate Genomes Nature. Jan, 2024 | Pubmed ID: 38030727 Genetic Characterization of the ALFA Study: Uncovering Genetic Profiles in the Alzheimer's Continuum Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Dec, 2023 | Pubmed ID: 38088508 CAAStools: a Toolbox to Identify and Test Convergent Amino Acid Substitutions Bioinformatics (Oxford, England). Oct, 2023 | Pubmed ID: 37846039 Understanding the Neurological Implications of Acute and Long COVID Using Brain Organoids Disease Models & Mechanisms. Jul, 2023 | Pubmed ID: 37458167 A Global Catalog of Whole-genome Diversity from 233 Primate Species Science (New York, N.Y.). Jun, 2023 | Pubmed ID: 37262161 The Landscape of Tolerated Genetic Variation in Humans and Primates Science (New York, N.Y.). Jun, 2023 | Pubmed ID: 37262156 The Landscape of Tolerated Genetic Variation in Humans and Primates BioRxiv : the Preprint Server for Biology. May, 2023 | Pubmed ID: 37205491 Evolutionary Constraint and Innovation Across Hundreds of Placental Mammals Science (New York, N.Y.). Apr, 2023 | Pubmed ID: 37104599 Polygenic Risk Scores Enhance Prediction of Body Mass Index Increase in Individuals with a First Episode of Psychosis European Psychiatry : the Journal of the Association of European Psychiatrists. Feb, 2023 | Pubmed ID: 36852609 Genetically Predicted Telomere Length and Alzheimer's Disease Endophenotypes: a Mendelian Randomization Study Alzheimer's Research & Therapy. Nov, 2022 | Pubmed ID: 36345036 Brain Transcriptomic Profiling Reveals Common Alterations Across Neurodegenerative and Psychiatric Disorders Computational and Structural Biotechnology Journal. 2022 | Pubmed ID: 36090817 Genetically Predicted Telomere Length and Its Relationship with Neurodegenerative Diseases and Life Expectancy Computational and Structural Biotechnology Journal. 2022 | Pubmed ID: 36051868 Look-alike Humans Identified by Facial Recognition Algorithms Show Genetic Similarities Cell Reports. Aug, 2022 | Pubmed ID: 36001980 Author Correction: Comparative and Demographic Analysis of Orang-utan Genomes Nature. Aug, 2022 | Pubmed ID: 35962045 Prepandemic Alzheimer Disease Biomarkers and Anxious-Depressive Symptoms During the COVID-19 Confinement in Cognitively Unimpaired Adults Neurology. Oct, 2022 | Pubmed ID: 35918160 Human Herpesvirus Diversity is Altered in HLA Class I Binding Peptides Proceedings of the National Academy of Sciences of the United States of America. May, 2022 | Pubmed ID: 35486690 Beacon V2 and Beacon Networks: A "lingua Franca" for Federated Data Discovery in Biomedical Genomics, and Beyond Human Mutation. Jun, 2022 | Pubmed ID: 35297548 International Federation of Genomic Medicine Databases Using GA4GH Standards Cell Genomics. Nov, 2021 | Pubmed ID: 35128509 GA4GH: International Policies and Standards for Data Sharing Across Genomic Research and Healthcare Cell Genomics. Nov, 2021 | Pubmed ID: 35072136 Correction: Telford Et Al. Expanding the Geographic Characterisation of Epstein-Barr Virus Variation Through Gene-Based Approaches. 2020, , 1686 Microorganisms. Nov, 2021 | Pubmed ID: 34835535 Single-cell Transcriptional Changes in Neurodegenerative Diseases Neuroscience. Dec, 2021 | Pubmed ID: 34748859 The Genetic Impact of an Ebola Outbreak on a Wild Gorilla Population BMC Genomics. Oct, 2021 | Pubmed ID: 34635054 Coexpression of the Discoidin Domain Receptor 1 Gene with Oligodendrocyte-related and Schizophrenia Risk Genes in the Developing and Adult Human Brain Brain and Behavior. Aug, 2021 | Pubmed ID: 34323026 Comparative Analysis of Mammal Genomes Unveils Key Genomic Variability for Human Life Span Molecular Biology and Evolution. Oct, 2021 | Pubmed ID: 34297086 Genetic Predisposition to Alzheimer's Disease Is Associated with Enlargement of Perivascular Spaces in Centrum Semiovale Region Genes. May, 2021 | Pubmed ID: 34072165 Epigenomic Profiling of Primate Lymphoblastoid Cell Lines Reveals the Evolutionary Patterns of Epigenetic Activities in Gene Regulatory Architectures Nature Communications. May, 2021 | Pubmed ID: 34035253 Inversions and Genomic Differentiation After Secondary Contact: When Drift Contributes to Maintenance, Not Loss, of Differentiation Evolution; International Journal of Organic Evolution. Jun, 2021 | Pubmed ID: 33844299 Variation in Predicted COVID-19 Risk Among Lemurs and Lorises American Journal of Primatology. Jun, 2021 | Pubmed ID: 33792947 Variation in Predicted COVID-19 Risk Among Lemurs and Lorises BioRxiv : the Preprint Server for Biology. Feb, 2021 | Pubmed ID: 33564767 The Shared Genetic Architecture of Schizophrenia, Bipolar Disorder and Lifespan Human Genetics. Mar, 2021 | Pubmed ID: 32772156 The Presence of Human Herpesvirus 6 in the Brain in Health and Disease Biomolecules. Nov, 2020 | Pubmed ID: 33172107 Expanding the Geographic Characterisation of Epstein-Barr Virus Variation Through Gene-Based Approaches Microorganisms. Oct, 2020 | Pubmed ID: 33138327 Extreme Differences Between Human Germline and Tumor Mutation Densities Are Driven by Ancestral Human-specific Deviations Nature Communications. May, 2020 | Pubmed ID: 32427823 Copy Number Variants and Fixed Duplications Among 198 Rhesus Macaques (Macaca Mulatta) PLoS Genetics. May, 2020 | Pubmed ID: 32392208 A New Risk Variant for Multiple Sclerosis at 11q23.3 Is Associated with Expansion of Circulating Regulatory T Cells Journal of Clinical Medicine. Feb, 2020 | Pubmed ID: 32110891 Evolutionary History, Genomic Adaptation to Toxic Diet, and Extinction of the Carolina Parakeet Current Biology : CB. Jan, 2020 | Pubmed ID: 31839456 Genome-phenome Explorer (GePhEx): a Tool for the Visualization and Interpretation of Phenotypic Relationships Supported by Genetic Evidence Bioinformatics (Oxford, England). Feb, 2020 | Pubmed ID: 31393550 A Pharmacogenetic Study Implicates in the Response to Interferon-β in Multiple Sclerosis Multiple Sclerosis (Houndmills, Basingstoke, England). Aug, 2020 | Pubmed ID: 31221001 Author Correction: Leveraging European Infrastructures to Access 1 Million Human Genomes by 2022 Nature Reviews. Genetics. Nov, 2019 | Pubmed ID: 31520075 Leveraging European Infrastructures to Access 1 Million Human Genomes by 2022 Nature Reviews. Genetics. Nov, 2019 | Pubmed ID: 31455890 Reply To: Retesting the Influences of Mutation Accumulation and Antagonistic Pleiotropy on Human Senescence and Disease Nature Ecology & Evolution. Jul, 2019 | Pubmed ID: 31235924 Genome-wide Association Analyses of Risk Tolerance and Risky Behaviors in over 1 Million Individuals Identify Hundreds of Loci and Shared Genetic Influences Nature Genetics. Feb, 2019 | Pubmed ID: 30643258 Effect of Collapsed Duplications on Diversity Estimates: What to Expect Genome Biology and Evolution. Nov, 2018 | Pubmed ID: 30364947 Biological Processes Modulating Longevity Across Primates: A Phylogenetic Genome-Phenome Analysis Molecular Biology and Evolution. Aug, 2018 | Pubmed ID: 29788292 Author Correction: Potential Damaging Mutation in LRP5 from Genome Sequencing of the First Reported Chimpanzee with the Chiari Malformation Scientific Reports. May, 2018 | Pubmed ID: 29728620 Replicability and Prediction: Lessons and Challenges from GWAS Trends in Genetics : TIG. Jul, 2018 | Pubmed ID: 29716745 Author Correction: Whole Genome Diversity of Inherited Chromosomally Integrated HHV-6 Derived from Healthy Individuals of Diverse Geographic Origin Scientific Reports. Apr, 2018 | Pubmed ID: 29662094 Whole Genome Diversity of Inherited Chromosomally Integrated HHV-6 Derived from Healthy Individuals of Diverse Geographic Origin Scientific Reports. Feb, 2018 | Pubmed ID: 29472617 NLRP3 Polymorphisms and Response to Interferon-beta in Multiple Sclerosis Patients Multiple Sclerosis (Houndmills, Basingstoke, England). Oct, 2018 | Pubmed ID: 29117789 The Impact of Endogenous Content, Replicates and Pooling on Genome Capture from Faecal Samples Molecular Ecology Resources. Mar, 2018 | Pubmed ID: 29058768 Transcriptional Network Analysis in Frontal Cortex in Lewy Body Diseases with Focus on Dementia with Lewy Bodies Brain Pathology (Zurich, Switzerland). May, 2018 | Pubmed ID: 28321951 Similar Genomic Proportions of Copy Number Variation Within Gray Wolves and Modern Dog Breeds Inferred from Whole Genome Sequencing BMC Genomics. Dec, 2017 | Pubmed ID: 29258433 Potential Damaging Mutation in LRP5 from Genome Sequencing of the First Reported Chimpanzee with the Chiari Malformation Scientific Reports. Nov, 2017 | Pubmed ID: 29123202 A 3-way Hybrid Approach to Generate a New High-quality Chimpanzee Reference Genome (Pan_tro_3.0) GigaScience. Nov, 2017 | Pubmed ID: 29092041 Antagonistic Pleiotropy and Mutation Accumulation Influence Human Senescence and Disease Nature Ecology & Evolution. Jan, 2017 | Pubmed ID: 28812720 Genetic Factors Affecting EBV Copy Number in Lymphoblastoid Cell Lines Derived from the 1000 Genome Project Samples PloS One. 2017 | Pubmed ID: 28654678 Erratum To: Interhemispheric Gene Expression Differences in the Cerebral Cortex of Humans and Macaque Monkeys Brain Structure & Function. Sep, 2017 | Pubmed ID: 28488187 Interhemispheric Gene Expression Differences in the Cerebral Cortex of Humans and Macaque Monkeys Brain Structure & Function. Sep, 2017 | Pubmed ID: 28317062 Properties of Human Disease Genes and the Role of Genes Linked to Mendelian Disorders in Complex Disease Aetiology Human Molecular Genetics. Feb, 2017 | Pubmed ID: 28053046 Combining Multiple Hypothesis Testing with Machine Learning Increases the Statistical Power of Genome-wide Association Studies Scientific Reports. Nov, 2016 | Pubmed ID: 27892471 Natural Selection in the Great Apes Molecular Biology and Evolution. Dec, 2016 | Pubmed ID: 27795229 Chimpanzee Genomic Diversity Reveals Ancient Admixture with Bonobos Science (New York, N.Y.). Oct, 2016 | Pubmed ID: 27789843 Differences in Molecular Evolutionary Rates Among MicroRNAs in the Human and Chimpanzee Genomes BMC Genomics. Jul, 2016 | Pubmed ID: 27474039 Demographic History of the Genus Pan Inferred from Whole Mitochondrial Genome Reconstructions Genome Biology and Evolution. Jul, 2016 | Pubmed ID: 27345955 Assessing Statistical Significance in Multivariable Genome Wide Association Analysis Bioinformatics (Oxford, England). Jul, 2016 | Pubmed ID: 27153677 Functional Implications of Human-Specific Changes in Great Ape MicroRNAs PloS One. 2016 | Pubmed ID: 27105073 267 Spanish Exomes Reveal Population-Specific Differences in Disease-Related Genetic Variation Molecular Biology and Evolution. May, 2016 | Pubmed ID: 26764160 SeDuS: Segmental Duplication Simulator Bioinformatics (Oxford, England). Jan, 2016 | Pubmed ID: 26358728 Pharmacogenomic Study in Patients with Multiple Sclerosis: Responders and Nonresponders to IFN-β Neurology(R) Neuroimmunology & Neuroinflammation. Oct, 2015 | Pubmed ID: 26445728 The European Genome-phenome Archive of Human Data Consented for Biomedical Research Nature Genetics. Jul, 2015 | Pubmed ID: 26111507 Genetic and Clinical Factors Associated with Chronic Postsurgical Pain After Hernia Repair, Hysterectomy, and Thoracotomy: A Two-year Multicenter Cohort Study Anesthesiology. May, 2015 | Pubmed ID: 25985024 Analysis of Five Gene Sets in Chimpanzees Suggests Decoupling Between the Action of Selection on Protein-Coding and on Noncoding Elements Genome Biology and Evolution. May, 2015 | Pubmed ID: 25977458 Mendelian Genes for Parkinson's Disease Contribute to the Sporadic Forms of the Disease Human Molecular Genetics. Apr, 2015 | Pubmed ID: 25504046 Interplay of Interlocus Gene Conversion and Crossover in Segmental Duplications Under a Neutral Scenario G3 (Bethesda, Md.). Jun, 2014 | Pubmed ID: 24906640 Genetic Variation in the TP53 Pathway and Bladder Cancer Risk. a Comprehensive Analysis PloS One. 2014 | Pubmed ID: 24818791 Genomic Analysis of the Blood Attributed to Louis XVI (1754-1793), King of France Scientific Reports. Apr, 2014 | Pubmed ID: 24763138 Genome-wide Analysis of Wild-type Epstein-Barr Virus Genomes Derived from Healthy Individuals of the 1,000 Genomes Project Genome Biology and Evolution. Apr, 2014 | Pubmed ID: 24682154 Pool and Conquer: New Tricks for (c)old Problems Molecular Ecology. Apr, 2014 | Pubmed ID: 24667009 Application of Multi-SNP Approaches Bayesian LASSO and AUC-RF to Detect Main Effects of Inflammatory-gene Variants Associated with Bladder Cancer Risk PloS One. 2013 | Pubmed ID: 24391818 Great Ape Genetic Diversity and Population History Nature. Jul, 2013 | Pubmed ID: 23823723 High Trans-ethnic Replicability of GWAS Results Implies Common Causal Variants PLoS Genetics. Jun, 2013 | Pubmed ID: 23785302 The Genome Sequencing of an Albino Western Lowland Gorilla Reveals Inbreeding in the Wild BMC Genomics. May, 2013 | Pubmed ID: 23721540 Accelerated Exon Evolution Within Primate Segmental Duplications Genome Biology. Jan, 2013 | Pubmed ID: 23360670 Identification of a Functional Variant in the KIF5A-CYP27B1-METTL1-FAM119B Locus Associated with Multiple Sclerosis Journal of Medical Genetics. Jan, 2013 | Pubmed ID: 23160276 The Genome of Melon (Cucumis Melo L.) Proceedings of the National Academy of Sciences of the United States of America. Jul, 2012 | Pubmed ID: 22753475 HeT-A_pi1, a PiRNA Target Sequence in the Drosophila Telomeric Retrotransposon HeT-A, is Extremely Conserved Across Copies and Species PloS One. 2012 | Pubmed ID: 22629389 Copy Number Variation Analysis in the Great Apes Reveals Species-specific Patterns of Structural Variation Genome Research. Oct, 2011 | Pubmed ID: 21824994 Gorilla Genome Structural Variation Reveals Evolutionary Parallelisms with Chimpanzee Genome Research. Oct, 2011 | Pubmed ID: 21685127 Genome-wide Association Studies Pipeline (GWASpi): a Desktop Application for Genome-wide SNP Analysis and Management Bioinformatics (Oxford, England). Jul, 2011 | Pubmed ID: 21586520 Analisi Comparativa E Demografiche Dei Genomi Di Orang-utan Nature. Jan, 2011 | Pubmed ID: 21270892 Recent Human Evolution Has Shaped Geographical Differences in Susceptibility to Disease BMC Genomics. Jan, 2011 | Pubmed ID: 21261943 Selection Upon Genome Architecture: Conservation of Functional Neighborhoods with Changing Genes PLoS Computational Biology. Oct, 2010 | Pubmed ID: 20949098 Chromosomal Speciation Revisited: Rearranging Theory with Pieces of Evidence Trends in Ecology & Evolution. Nov, 2010 | Pubmed ID: 20817305 Decay of Linkage Disequilibrium Within Genes Across HGDP-CEPH Human Samples: Most Population Isolates Do Not Show Increased LD BMC Genomics. Jul, 2009 | Pubmed ID: 19638193 Genoeconomics: Promises and Caveats for a New Field Annals of the New York Academy of Sciences. Jun, 2009 | Pubmed ID: 19580553 Interrogating 11 Fast-evolving Genes for Signatures of Recent Positive Selection in Worldwide Human Populations Molecular Biology and Evolution. Oct, 2009 | Pubmed ID: 19578157 Allele-specific Gene Expression is Widespread Across the Genome and Biological Processes PloS One. 2009 | Pubmed ID: 19127300 Identification of a Novel Risk Locus for Multiple Sclerosis at 13q31.3 by a Pooled Genome-wide Scan of 500,000 Single Nucleotide Polymorphisms PloS One. 2008 | Pubmed ID: 18941528 The Genomic Distribution of Intraspecific and Interspecific Sequence Divergence of Human Segmental Duplications Relative to Human/chimpanzee Chromosomal Rearrangements BMC Genomics. Aug, 2008 | Pubmed ID: 18699995 Balancing Selection is the Main Force Shaping the Evolution of Innate Immunity Genes Journal of Immunology (Baltimore, Md. : 1950). Jul, 2008 | Pubmed ID: 18606686 SNP Analysis to Results (SNPator): a Web-based Environment Oriented to Statistical Genomics Analyses Upon SNP Data Bioinformatics (Oxford, England). Jul, 2008 | Pubmed ID: 18515823 Statistical Power Analysis of Neutrality Tests Under Demographic Expansions, Contractions and Bottlenecks with Recombination Genetics. May, 2008 | Pubmed ID: 18493071 L'associazione Tra Riarrangiamenti Cromosomici Ed Evoluzione Genica in Esseri Umani E Gli Scimpanzé Genome Biology. 2007 | Pubmed ID: 17971225 Extreme Individual Marker F(ST )values Do Not Imply Population-specific Selection in Humans: the NRG1 Example Human Genetics. Jul, 2007 | Pubmed ID: 17457614 Patterns and Rates of Intron Divergence Between Humans and Chimpanzees Genome Biology. 2007 | Pubmed ID: 17309804 Frequent Appearance of Novel Protein-coding Sequences by Frameshift Translation Genomics. Dec, 2006 | Pubmed ID: 16890400 The Portability of TagSNPs Across Populations: a Worldwide Survey Genome Research. Mar, 2006 | Pubmed ID: 16467560 The Prion Protein Gene in Humans Revisited: Lessons from a Worldwide Resequencing Study Genome Research. Feb, 2006 | Pubmed ID: 16369046 Association Cluster Detector: a Tool for Heuristic Detection of Significance Clusters in Whole-genome Scans Bioinformatics (Oxford, England). Sep, 2005 | Pubmed ID: 16204099 Chromosomal Rearrangements Are Associated with Higher Rates of Molecular Evolution in Mammals Gene. Jul, 2005 | Pubmed ID: 15951139 Geographic Stratification of Linkage Disequilibrium: a Worldwide Population Study in a Region of Chromosome 22 Human Genomics. Nov, 2004 | Pubmed ID: 15606995 Chromosomal Rearrangements and the Genomic Distribution of Gene-expression Divergence in Humans and Chimpanzees Trends in Genetics : TIG. Nov, 2004 | Pubmed ID: 15475109 Positive Selection in MAOA Gene is Human Exclusive: Determination of the Putative Amino Acid Change Selected in the Human Lineage Human Genetics. Oct, 2004 | Pubmed ID: 15349769 Dynamics of a Human Interparalog Gene Conversion Hotspot Genome Research. May, 2004 | Pubmed ID: 15123583 Accumulating Postzygotic Isolation Genes in Parapatry: a New Twist on Chromosomal Speciation Evolution; International Journal of Organic Evolution. Mar, 2003 | Pubmed ID: 12703935 Chromosomal Speciation and Molecular Divergence--accelerated Evolution in Rearranged Chromosomes Science (New York, N.Y.). Apr, 2003 | Pubmed ID: 12690198 Author Spotlight: Optimizing the Neurovascular Development of Human Brain Organoid in Chick Embryo Luciano Fiore1,2, Jan Arderiu3, Andrea Martí-Sarrias3,4, Isabel Turpín3,4, Ruth I. Pareja3,5, Arcadi Navarro5,6,7,8, Mariana Holubiec2,9, Julieta Bianchelli9, Tomas Falzone2,9, Gonzalo Spelzini1,2, Gabriel Scicolone1,2, Sandra Acosta3,4 1Instituto de Biología Celular y Neurociencias “Prof. E. De Robertis” (IBCN), CONICET - Universidad de Buenos Aires, 2Facultad de Medicina, Departamento de Biología Celular, Histología, Embriología y Genética, Universidad de Buenos Aires, 3Institute of Neurosciences, Pathology and Experimental Therapeutics Dept, University of Barcelona, 4Functional Neurogenomics Group, Neurodevelopmental Disorders, IDIBELL, L’Hospitalet de Llobregat, 5IBE, Institute of Evolutionary Biology (UPF-CSIC), Department of Medicine and Life Sciences, Universitat Pompeu Fabra, 6Institució Catalana de Recerca i Estudis Avançats (ICREA) and Universitat Pompeu Fabra, 7Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 8BarcelonaBeta Brain Research Center, Pasqual Maragall Foundation, 9Instituto de Investigación en Biomedicina (IBioBA) – CONICET – Instituto Partner de la Sociedad Max Planck JoVE 65710 Biologia dello sviluppo
Author Spotlight: Optimizing the Neurovascular Development of Human Brain Organoid in Chick Embryo Luciano Fiore1,2, Jan Arderiu3, Andrea Martí-Sarrias3,4, Isabel Turpín3,4, Ruth I. Pareja3,5, Arcadi Navarro5,6,7,8, Mariana Holubiec2,9, Julieta Bianchelli9, Tomas Falzone2,9, Gonzalo Spelzini1,2, Gabriel Scicolone1,2, Sandra Acosta3,4 1Instituto de Biología Celular y Neurociencias “Prof. E. De Robertis” (IBCN), CONICET - Universidad de Buenos Aires, 2Facultad de Medicina, Departamento de Biología Celular, Histología, Embriología y Genética, Universidad de Buenos Aires, 3Institute of Neurosciences, Pathology and Experimental Therapeutics Dept, University of Barcelona, 4Functional Neurogenomics Group, Neurodevelopmental Disorders, IDIBELL, L’Hospitalet de Llobregat, 5IBE, Institute of Evolutionary Biology (UPF-CSIC), Department of Medicine and Life Sciences, Universitat Pompeu Fabra, 6Institució Catalana de Recerca i Estudis Avançats (ICREA) and Universitat Pompeu Fabra, 7Center for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 8BarcelonaBeta Brain Research Center, Pasqual Maragall Foundation, 9Instituto de Investigación en Biomedicina (IBioBA) – CONICET – Instituto Partner de la Sociedad Max Planck JoVE 65710 Biologia dello sviluppo