Birger Brodin Department of Pharmacy, The Faculty of Health and Medical Sciences University of Copenhagen Biography Publications Institution JoVE Articles Birger Brodin has not added a biography. If you are Birger Brodin and would like to personalize this page please email our Author Liaison for assistance. Publications Culture-induced Changes in MRNA Expression Levels of Efflux and SLC-transporters in Brain Endothelial Cells Fluids and Barriers of the CNS. Apr, 2020 | Pubmed ID: 32321539 The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP Cells. Mar, 2020 | Pubmed ID: 32143347 Effects of Oxygen-glucose Deprivation (OGD) on Barrier Properties and MRNA Transcript Levels of Selected Marker Proteins in Brain Endothelial Cells/astrocyte Co-cultures PloS One. 2019 | Pubmed ID: 31425564 Evaluating the Involvement of Cerebral Microvascular Endothelial Na/K-ATPase and Na-K-2Cl Co-transporter in Electrolyte Fluxes in an In vitro Blood-brain Barrier Model of Dehydration Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 03, 2019 | Pubmed ID: 28994331 Validation of Reference Genes for Normalization of Real-time Quantitative PCR Studies of Gene Expression in Brain Capillary Endothelial Cells Cultured in Vitro Molecular and Cellular Neurosciences. 12, 2018 | Pubmed ID: 30315869 Stimulation-induced Increases in Cerebral Blood Flow and Local Capillary Vasoconstriction Depend on Conducted Vascular Responses Proceedings of the National Academy of Sciences of the United States of America. 06, 2018 | Pubmed ID: 29866853 The Insulin Receptor is Expressed and Functional in Cultured Blood-brain Barrier Endothelial Cells but Does Not Mediate Insulin Entry from Blood to Brain American Journal of Physiology. Endocrinology and Metabolism. 10, 2018 | Pubmed ID: 29584446 Data Demonstrating the Challenges of Determining the Kinetic Parameters of P-gp Mediated Transport of Low-water Soluble Substrates Data in Brief. Feb, 2018 | Pubmed ID: 29541662 Correction To: Current Research into Brain Barriers and the Delivery of Therapeutics for Neurological Diseases: a Report on CNS Barrier Congress London, UK, 2017 Fluids and Barriers of the CNS. 01, 2018 | Pubmed ID: 29329565 Characterization of the IPEC-J2 MDR1 (iP-gp) Cell Line As a Tool for Identification of P-gp Substrates European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jan, 2018 | Pubmed ID: 29146563 Current Research into Brain Barriers and the Delivery of Therapeutics for Neurological Diseases: a Report on CNS Barrier Congress London, UK, 2017 Fluids and Barriers of the CNS. Nov, 2017 | Pubmed ID: 29110676 Glutamate Transporters in the Blood-Brain Barrier Advances in Neurobiology. 2017 | Pubmed ID: 28828617 Routes for Drug Translocation Across the Blood-Brain Barrier: Exploiting Peptides As Delivery Vectors Journal of Pharmaceutical Sciences. 09, 2017 | Pubmed ID: 28501469 A Critical View on In Vitro Analysis of P-glycoprotein (P-gp) Transport Kinetics Journal of Pharmaceutical Sciences. 09, 2017 | Pubmed ID: 28438535 Bidirectional Apical-basal Traffic of the Cation-independent Mannose-6-phosphate Receptor in Brain Endothelial Cells Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Jul, 2017 | Pubmed ID: 28337939 Characterization of the L-glutamate Clearance Pathways Across the Blood-brain Barrier and the Effect of Astrocytes in an In vitro Blood-brain Barrier Model Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Dec, 2017 | Pubmed ID: 28145808 Transferrin Receptor Expression and Role in Transendothelial Transport of Transferrin in Cultured Brain Endothelial Monolayers Molecular and Cellular Neurosciences. Oct, 2016 | Pubmed ID: 27567687 In Vitro Blood-brain Barrier Permeability Predictions for GABAA Receptor Modulating Piperine Analogs European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. Jun, 2016 | Pubmed ID: 27018328 Stroke and Drug Delivery--In Vitro Models of the Ischemic Blood-Brain Barrier Journal of Pharmaceutical Sciences. Feb, 2016 | Pubmed ID: 26869407 In vitro Models of the Blood-brain Barrier: An Overview of Commonly Used Brain Endothelial Cell Culture Models and Guidelines for Their Use Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. May, 2016 | Pubmed ID: 26868179 The Putative P-gp Inhibitor Telmisartan Does Not Affect the Transcellular Permeability and Cellular Uptake of the Calcium Channel Antagonist Verapamil in the P-glycoprotein Expressing Cell Line MDCK II MDR1 Pharmacology Research & Perspectives. Aug, 2015 | Pubmed ID: 26171231 In Vitro Blood-Brain Barrier Models-An Overview of Established Models and New Microfluidic Approaches Journal of Pharmaceutical Sciences. Sep, 2015 | Pubmed ID: 25630899 Intestinal Absorption of the Antiepileptic Drug Substance Vigabatrin is Altered by Infant Formula in Vitro and in Vivo Pharmacology Research & Perspectives. Apr, 2014 | Pubmed ID: 25505585 Glutamate Efflux at the Blood-brain Barrier: Cellular Mechanisms and Potential Clinical Relevance Archives of Medical Research. Nov, 2014 | Pubmed ID: 25446623 An Electrically Tight in Vitro Blood-brain Barrier Model Displays Net Brain-to-blood Efflux of Substrates for the ABC Transporters, P-gp, Bcrp and Mrp-1 The AAPS Journal. Sep, 2014 | Pubmed ID: 24934296 In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt-DALDA Analogues ACS Medicinal Chemistry Letters. Apr, 2014 | Pubmed ID: 24839540 Generation of Primary Cultures of Bovine Brain Endothelial Cells and Setup of Cocultures with Rat Astrocytes Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 24510879 PAT1 (SLC36A1) Shows Nuclear Localization and Affects Growth of Smooth Muscle Cells from Rats American Journal of Physiology. Endocrinology and Metabolism. Jan, 2014 | Pubmed ID: 24222668 The Absorptive Flux of the Anti-epileptic Drug Substance Vigabatrin is Carrier-mediated Across Caco-2 Cell Monolayers European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jan, 2014 | Pubmed ID: 24008184 Basolateral Glycylsarcosine (Gly-Sar) Transport in Caco-2 Cell Monolayers is PH Dependent The Journal of Pharmacy and Pharmacology. Jul, 2013 | Pubmed ID: 23738724 Identification and Characterization of a Novel Nontranslated Sequence Variant of the Human Intestinal Di-/Tripeptide Transporter, HPEPT1 International Journal of Peptides. 2012 | Pubmed ID: 23346117 체 외에서 잠재적으로 CNS 액티브 수선화과 미치 죠 시리즈의 P-당단백질 상호 작용 평가 The Journal of Pharmacy and Pharmacology. Nov, 2012 | Pubmed ID: 23058055 Carrier-mediated γ-aminobutyric Acid Transport Across the Basolateral Membrane of Human Intestinal Caco-2 Cell Monolayers European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. Jun, 2012 | Pubmed ID: 22452873 In Vitro Evidence for the Brain Glutamate Efflux Hypothesis: Brain Endothelial Cells Cocultured with Astrocytes Display a Polarized Brain-to-blood Transport of Glutamate Glia. May, 2012 | Pubmed ID: 22392649 Calu-3 Cells Grown Under AIC and LCC Conditions: Implications for Dipeptide Uptake and Transepithelial Transport of Substances European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. May, 2011 | Pubmed ID: 21195173 Affinity and Translocation Relationships Via HPEPT1 of H-X Aa-Ser-OH Dipeptides: Evaluation of H-Phe-Ser-OH As a Pro-moiety for Ibuprofen and Benzoic Acid Prodrugs European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. Feb, 2011 | Pubmed ID: 21147219 Paracellular Tightness and Claudin-5 Expression is Increased in the BCEC/astrocyte Blood-brain Barrier Model by Increasing Media Buffer Capacity During Growth The AAPS Journal. Dec, 2010 | Pubmed ID: 20967520 Ibuprofen is a Non-competitive Inhibitor of the Peptide Transporter HPEPT1 (SLC15A1): Possible Interactions Between HPEPT1 Substrates and Ibuprofen British Journal of Pharmacology. Dec, 2010 | Pubmed ID: 20726987 A Quantitative Structure-activity Relationship for Translocation of Tripeptides Via the Human Proton-coupled Peptide Transporter, HPEPT1 (SLC15A1) The AAPS Journal. Sep, 2010 | Pubmed ID: 20449699 5-Hydroxy-L-tryptophan Alters Gaboxadol Pharmacokinetics in Rats: Involvement of PAT1 and ROat1 in Gaboxadol Absorption and Elimination European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jan, 2010 | Pubmed ID: 19900542 In Vitro Cutaneous Application of ISCOMs on Human Skin Enhances Delivery of Hydrophobic Model Compounds Through the Stratum Corneum The AAPS Journal. Dec, 2009 | Pubmed ID: 19862629 Discovery of Ligands for the Human Intestinal Di-/Tripeptide Transporter (hPEPT1) Using a QSAR-assisted Virtual Screening Strategy ChemMedChem. Sep, 2009 | Pubmed ID: 19557803 Cloning of the Pig PEPT2 (pPEPT2) and Characterization of the Effects of Epidermal Growth Factor (EGF) on PPEPT2-mediated Peptide Uptake in the Renal Porcine Cell Line LLC-PK1 European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Apr, 2008 | Pubmed ID: 18295462 HPEPT1 is Responsible for Uptake and Transport of Gly-Sar in the Human Bronchial Airway Epithelial Cell-line Calu-3 Pflugers Archiv : European Journal of Physiology. Jun, 2008 | Pubmed ID: 18094991 세포칼슘 측정 및 칼슘 이미징 연구를 위한 뇌 모세관 과구 배양 Sofie Hørlyck1, Hans Christian Cederberg Helms1, Birger Brodin1 1Department of Pharmacy, The Faculty of Health and Medical Sciences, University of Copenhagen JoVE 61253 Neuroscienze
세포칼슘 측정 및 칼슘 이미징 연구를 위한 뇌 모세관 과구 배양 Sofie Hørlyck1, Hans Christian Cederberg Helms1, Birger Brodin1 1Department of Pharmacy, The Faculty of Health and Medical Sciences, University of Copenhagen JoVE 61253 Neuroscienze