Brendan W. Wren Faculty of Infectious & Tropical Diseases London School of Hygiene & Tropical Medicine Biography Publications Institution JoVE Articles Brendan W. Wren has not added a biography. If you are Brendan W. Wren and would like to personalize this page please email our Author Liaison for assistance. Publications Generation of a Tn5 Transposon Library in Haemophilus Parasuis and Analysis by Transposon-directed Insertion-site Sequencing (TraDIS) Veterinary Microbiology. Oct, 2013 | Pubmed ID: 23928120 Clostridium Difficile Modulates Host Innate Immunity Via Toxin-independent and Dependent Mechanism(s) PloS One. 2013 | Pubmed ID: 23922820 Development of a Self-replicating Plasmid System for Mycoplasma Hyopneumoniae Veterinary Research. 2013 | Pubmed ID: 23895236 Gene Content and Diversity of the Loci Encoding Biosynthesis of Capsular Polysaccharides of the 15 Serovar Reference Strains of Haemophilus Parasuis Journal of Bacteriology. Sep, 2013 | Pubmed ID: 23873912 Bacteria Like Sharing Their Sweets Molecular Microbiology. Sep, 2013 | Pubmed ID: 23844892 Altered Innate Defenses in the Neonatal Gastrointestinal Tract in Response to Colonization by Neuropathogenic Escherichia Coli Infection and Immunity. Sep, 2013 | Pubmed ID: 23798529 The Agr Locus Regulates Virulence and Colonization Genes in Clostridium Difficile 027 Journal of Bacteriology. Aug, 2013 | Pubmed ID: 23772065 Improved Bacterial Mutagenesis by High-frequency Allele Exchange, Demonstrated in Clostridium Difficile and Streptococcus Suis Applied and Environmental Microbiology. Aug, 2013 | Pubmed ID: 23728809 Exploitation of Bacterial N-linked Glycosylation to Develop a Novel Recombinant Glycoconjugate Vaccine Against Francisella Tularensis Open Biology. 2013 | Pubmed ID: 23697804 Transcriptional Analysis of Temporal Gene Expression in Germinating Clostridium Difficile 630 Endospores PloS One. 2013 | Pubmed ID: 23691138 Yersinia Enterocolitica Provides the Link Between Thyroid-stimulating Antibodies and Their Germline Counterparts in Graves' Disease Journal of Immunology (Baltimore, Md. : 1950). Jun, 2013 | Pubmed ID: 23630351 Campylobacter Jejuni Lipooligosaccharide Sialylation, Phosphorylation, and Amide/ester Linkage Modifications Fine-tune Human Toll-like Receptor 4 Activation The Journal of Biological Chemistry. Jul, 2013 | Pubmed ID: 23629657 Characterization of Water and Wildlife Strains As a Subgroup of Campylobacter Jejuni Using DNA Microarrays Environmental Microbiology. Aug, 2013 | Pubmed ID: 23530835 Escherichia Coli Pathotypes in Pakistan from Consecutive Floods in 2010 and 2011 The American Journal of Tropical Medicine and Hygiene. Mar, 2013 | Pubmed ID: 23358642 Population Biology of Streptococcus Pneumoniae in West Africa: Multilocus Sequence Typing of Serotypes That Exhibit Different Predisposition to Invasive Disease and Carriage PloS One. 2013 | Pubmed ID: 23342041 Growth Inhibition of Pathogenic Bacteria by Sulfonylurea Herbicides Antimicrobial Agents and Chemotherapy. Mar, 2013 | Pubmed ID: 23263008 Emergence and Global Spread of Epidemic Healthcare-associated Clostridium Difficile Nature Genetics. Jan, 2013 | Pubmed ID: 23222960 Gene Function Hypotheses for the Campylobacter Jejuni Glycome Generated by a Logic-based Approach Journal of Molecular Biology. Jan, 2013 | Pubmed ID: 23103756 Characterisation of Clostridium Difficile Biofilm Formation, a Role for Spo0A PloS One. 2012 | Pubmed ID: 23236376 Comparative Phylogenomics of Streptococcus Pneumoniae Isolated from Invasive Disease and Nasopharyngeal Carriage from West Africans BMC Genomics. 2012 | Pubmed ID: 23107513 Campylobacter Jejuni Outer Membrane Vesicles Play an Important Role in Bacterial Interactions with Human Intestinal Epithelial Cells Infection and Immunity. Sep, 2012 | Pubmed ID: 22966047 Neutrophil Extracellular Traps Exhibit Antibacterial Activity Against Burkholderia Pseudomallei and Are Influenced by Bacterial and Host Factors Infection and Immunity. Nov, 2012 | Pubmed ID: 22927051 The Continually Evolving Clostridium Difficile Species Future Microbiology. Aug, 2012 | Pubmed ID: 22913354 Phenotypic and Genotypic Characterizations of Campylobacter Jejuni Isolated from the Broiler Meat Production Process Current Microbiology. Oct, 2012 | Pubmed ID: 22735984 The Clostridium Difficile Spo0A Gene is a Persistence and Transmission Factor Infection and Immunity. Aug, 2012 | Pubmed ID: 22615253 Recent Developments in Bacterial Protein Glycan Coupling Technology and Glycoconjugate Vaccine Design Journal of Medical Microbiology. Jul, 2012 | Pubmed ID: 22516134 Macro and Micro Diversity of Clostridium Difficile Isolates from Diverse Sources and Geographical Locations PloS One. 2012 | Pubmed ID: 22396735 Characterization of the Structurally Diverse N-linked Glycans of Campylobacter Species Journal of Bacteriology. May, 2012 | Pubmed ID: 22389484 Increase in Campylobacter Jejuni Invasion of Intestinal Epithelial Cells Under Low-oxygen Coculture Conditions That Reflect the in Vivo Environment Infection and Immunity. May, 2012 | Pubmed ID: 22354027 Evidence of Yersinia Pestis DNA from Fleas in an Endemic Plague Area of Zambia BMC Research Notes. 2012 | Pubmed ID: 22280795 Characterization of the Burkholderia Pseudomallei K96243 Capsular Polysaccharide I Coding Region Infection and Immunity. Mar, 2012 | Pubmed ID: 22252864 Identification of Immunogenic and Virulence-associated Campylobacter Jejuni Proteins Clinical and Vaccine Immunology : CVI. Feb, 2012 | Pubmed ID: 22155767 BμG@Sbase--a Microbial Gene Expression and Comparative Genomic Database Nucleic Acids Research. Jan, 2012 | Pubmed ID: 21948792 Emergence of New PCR Ribotypes from the Hypervirulent Clostridium Difficile 027 Lineage Journal of Medical Microbiology. Jan, 2012 | Pubmed ID: 21903827 The Campylobacter Jejuni NCTC11168 Capsule Prevents Excessive Cytokine Production by Dendritic Cells Medical Microbiology and Immunology. May, 2012 | Pubmed ID: 21863342 Hypervirulent Clostridium Difficile PCR-ribotypes Exhibit Resistance to Widely Used Disinfectants PloS One. 2011 | Pubmed ID: 22039420 Bacterial Epidemiology and Biology--lessons from Genome Sequencing Genome Biology. 2011 | Pubmed ID: 22027015 The Campylobacter Jejuni Transcriptional Regulator Cj1556 Plays a Role in the Oxidative and Aerobic Stress Response and is Important for Bacterial Survival in Vivo Journal of Bacteriology. Aug, 2011 | Pubmed ID: 21642451 The Analysis of Para-cresol Production and Tolerance in Clostridium Difficile 027 and 012 Strains BMC Microbiology. 2011 | Pubmed ID: 21527013 Identification and Characterisation of a Novel Adhesin Ifp in Yersinia Pseudotuberculosis BMC Microbiology. 2011 | Pubmed ID: 21527009 Genomic Variations Define Divergence of Water/wildlife-associated Campylobacter Jejuni Niche Specialists from Common Clonal Complexes Environmental Microbiology. Jun, 2011 | Pubmed ID: 21418497 Biofilm Development on Caenorhabditis Elegans by Yersinia is Facilitated by Quorum Sensing-dependent Repression of Type III Secretion PLoS Pathogens. 2011 | Pubmed ID: 21253572 Yersinia Pseudotuberculosis MntH Functions in Intracellular Manganese Accumulation, Which is Essential for Virulence and Survival in Cells Expressing Functional Nramp1 Microbiology (Reading, England). Apr, 2011 | Pubmed ID: 21183572 Effect of Chicken Meat Environment on Gene Expression of Campylobacter Jejuni and Its Relevance to Survival in Food International Journal of Food Microbiology. Mar, 2011 | Pubmed ID: 20858569 In-depth Genetic Analysis of Clostridium Difficile PCR-ribotype 027 Strains Reveals High Genome Fluidity Including Point Mutations and Inversions Gut Microbes. 7, 2010 | Pubmed ID: 21327033 Delineation of the Innate and Adaptive T-cell Immune Outcome in the Human Host in Response to Campylobacter Jejuni Infection PloS One. 2010 | Pubmed ID: 21085698 Glycoproteomics: a Powerful Tool for Characterizing the Diverse Glycoforms of Bacterial Pilins and Flagellins Biochemical Society Transactions. Oct, 2010 | Pubmed ID: 20863304 Systems Analysis of Bacterial Glycomes Biochemical Society Transactions. Oct, 2010 | Pubmed ID: 20863301 Liposomal Delivery of P-ialB and P-omp25 DNA Vaccines Improves Immunogenicity but Fails to Provide Full Protection Against B. Melitensis Challenge Genetic Vaccines and Therapy. 2010 | Pubmed ID: 20637091 Global Transcriptional Profiling of Burkholderia Pseudomallei Under Salt Stress Reveals Differential Effects on the Bsa Type III Secretion System BMC Microbiology. 2010 | Pubmed ID: 20540813 Administration of Capsule-selective Endosialidase E Minimizes Upregulation of Organ Gene Expression Induced by Experimental Systemic Infection with Escherichia Coli K1 Microbiology (Reading, England). Jul, 2010 | Pubmed ID: 20395269 Evolutionary Dynamics of Clostridium Difficile over Short and Long Time Scales Proceedings of the National Academy of Sciences of the United States of America. Apr, 2010 | Pubmed ID: 20368420 Insect Infection Model for Campylobacter Jejuni Reveals That O-methyl Phosphoramidate Has Insecticidal Activity The Journal of Infectious Diseases. Mar, 2010 | Pubmed ID: 20113177 Simple Sequence Repeats in Helicobacter Canadensis and Their Role in Phase Variable Expression and C-terminal Sequence Switching BMC Genomics. 2010 | Pubmed ID: 20105305 Steps Toward Broad-spectrum Therapeutics: Discovering Virulence-associated Genes Present in Diverse Human Pathogens BMC Genomics. 2009 | Pubmed ID: 19874620 Comparative Genome and Phenotypic Analysis of Clostridium Difficile 027 Strains Provides Insight into the Evolution of a Hypervirulent Bacterium Genome Biology. 2009 | Pubmed ID: 19781061 Recent Advances in Systems Microbiology Current Opinion in Microbiology. Oct, 2009 | Pubmed ID: 19748820 New Levels of Sophistication in the Transcriptional Landscape of Bacteria Genome Biology. 2009 | Pubmed ID: 19664196 Antibiotic Treatment of Clostridium Difficile Carrier Mice Triggers a Supershedder State, Spore-mediated Transmission, and Severe Disease in Immunocompromised Hosts Infection and Immunity. Sep, 2009 | Pubmed ID: 19564382 Clostridium Difficile--a Continually Evolving and Problematic Pathogen Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases. Dec, 2009 | Pubmed ID: 19539054 N-linked Glycosylation in Bacteria: an Unexpected Application Future Microbiology. May, 2009 | Pubmed ID: 19416010 Galleria Mellonella As an Alternative Infection Model for Yersinia Pseudotuberculosis Microbiology (Reading, England). May, 2009 | Pubmed ID: 19383703 Campylobacter Jejuni Glycosylation Island Important in Cell Charge, Legionaminic Acid Biosynthesis, and Colonization of Chickens Infection and Immunity. Jun, 2009 | Pubmed ID: 19307210 YtxR Acts As an Overriding Transcriptional off Switch for the Yersinia Enterocolitica Ysc-Yop Type 3 Secretion System Journal of Bacteriology. Jan, 2009 | Pubmed ID: 19011024 Development and Application of the Active Surveillance of Pathogens Microarray to Monitor Bacterial Gene Flux BMC Microbiology. 2008 | Pubmed ID: 18844996 Comparative Analysis of BI/NAP1/027 Hypervirulent Strains Reveals Novel Toxin B-encoding Gene (tcdB) Sequences Journal of Medical Microbiology. Jun, 2008 | Pubmed ID: 18480336 Microarray Analysis of the Transcriptional Responses of Clostridium Difficile to Environmental and Antibiotic Stress Journal of Medical Microbiology. Jun, 2008 | Pubmed ID: 18480334 Assessing the Role of P-cresol Tolerance in Clostridium Difficile Journal of Medical Microbiology. Jun, 2008 | Pubmed ID: 18480332 The Importance of the Rcs Phosphorelay in the Survival and Pathogenesis of the Enteropathogenic Yersiniae Microbiology (Reading, England). Apr, 2008 | Pubmed ID: 18375804 Campylobacter Jejuni-mediated Disease Pathogenesis: an Update Transactions of the Royal Society of Tropical Medicine and Hygiene. Feb, 2008 | Pubmed ID: 18023831 Comparative Genome Analyses of the Pathogenic Yersiniae Based on the Genome Sequence of Yersinia Enterocolitica Strain 8081 Advances in Experimental Medicine and Biology. 2007 | Pubmed ID: 17966400 Bacterial Pathogenomics Nature. Oct, 2007 | Pubmed ID: 17943120 The RovA Regulons of Yersinia Enterocolitica and Yersinia Pestis Are Distinct: Evidence That Many RovA-regulated Genes Were Acquired More Recently Than the Core Genome Molecular Microbiology. Oct, 2007 | Pubmed ID: 17784909 Deletion of a Previously Uncharacterized Flagellar-hook-length Control Gene FliK Modulates the Sigma54-dependent Regulon in Campylobacter Jejuni Microbiology (Reading, England). Sep, 2007 | Pubmed ID: 17768253 The Second Century of Campylobacter Research: Recent Advances, New Opportunities and Old Problems Current Opinion in Infectious Diseases. Oct, 2007 | Pubmed ID: 17762786 Commonality and Biosynthesis of the O-methyl Phosphoramidate Capsule Modification in Campylobacter Jejuni The Journal of Biological Chemistry. Sep, 2007 | Pubmed ID: 17675288 Re-annotation and Re-analysis of the Campylobacter Jejuni NCTC11168 Genome Sequence BMC Genomics. 2007 | Pubmed ID: 17565669 A Major Role for Intestinal Epithelial Nucleotide Oligomerization Domain 1 (NOD1) in Eliciting Host Bactericidal Immune Responses to Campylobacter Jejuni Cellular Microbiology. Oct, 2007 | Pubmed ID: 17521327 The Identification of Two Protective DNA Vaccines from a Panel of Five Plasmid Constructs Encoding Brucella Melitensis 16M Genes Vaccine. Jan, 2007 | Pubmed ID: 17049676 Clostridium Difficile Comes of Age Future Microbiology. Oct, 2006 | Pubmed ID: 17661635 The Complete Genome Sequence and Comparative Genome Analysis of the High Pathogenicity Yersinia Enterocolitica Strain 8081 PLoS Genetics. Dec, 2006 | Pubmed ID: 17173484 The Multidrug-resistant Human Pathogen Clostridium Difficile Has a Highly Mobile, Mosaic Genome Nature Genetics. Jul, 2006 | Pubmed ID: 16804543 Numerical Analysis of DNA Microarray Data of Campylobacter Jejuni Strains Correlated with Survival, Cytolethal Distending Toxin and Haemolysin Analyses International Journal of Medical Microbiology : IJMM. Oct, 2006 | Pubmed ID: 16782402 Application of Comparative Phylogenomics to Study the Evolution of Yersinia Enterocolitica and to Identify Genetic Differences Relating to Pathogenicity Journal of Bacteriology. May, 2006 | Pubmed ID: 16672618 Mucosal Immunization with a Urease B DNA Vaccine Induces Innate and Cellular Immune Responses Against Helicobacter Pylori Helicobacter. Apr, 2006 | Pubmed ID: 16579841 Serotype Differences and Lack of Biofilm Formation Characterize Yersinia Pseudotuberculosis Infection of the Xenopsylla Cheopis Flea Vector of Yersinia Pestis Journal of Bacteriology. Feb, 2006 | Pubmed ID: 16428415 Intestinal Innate Immunity to Campylobacter Jejuni Results in Induction of Bactericidal Human Beta-defensins 2 and 3 Infection and Immunity. Nov, 2005 | Pubmed ID: 16239524 Comparative Phylogenomics of the Food-borne Pathogen Campylobacter Jejuni Reveals Genetic Markers Predictive of Infection Source Proceedings of the National Academy of Sciences of the United States of America. Nov, 2005 | Pubmed ID: 16230626 Comparative Phylogenomics of Pathogenic Bacteria by Microarray Analysis Current Opinion in Microbiology. Oct, 2005 | Pubmed ID: 16125441 Explorative Multifactor Approach for Investigating Global Survival Mechanisms of Campylobacter Jejuni Under Environmental Conditions Applied and Environmental Microbiology. Apr, 2005 | Pubmed ID: 15812042 The Campylobacter Jejuni Glycome FEMS Microbiology Reviews. Apr, 2005 | Pubmed ID: 15808749 Functional Analysis of the Campylobacter Jejuni N-linked Protein Glycosylation Pathway Molecular Microbiology. Mar, 2005 | Pubmed ID: 15752194 Protein Glycosylation in Bacterial Mucosal Pathogens Nature Reviews. Microbiology. Mar, 2005 | Pubmed ID: 15738950 Revised Nomenclature of Clostridium Difficile Toxins and Associated Genes Journal of Medical Microbiology. Feb, 2005 | Pubmed ID: 15673503 The Complete Genome Sequence of Francisella Tularensis, the Causative Agent of Tularemia Nature Genetics. Feb, 2005 | Pubmed ID: 15640799 Analysis of Campylobacter Jejuni Capsular Loci Reveals Multiple Mechanisms for the Generation of Structural Diversity and the Ability to Form Complex Heptoses Molecular Microbiology. Jan, 2005 | Pubmed ID: 15612919 Invertebrates As a Source of Emerging Human Pathogens Nature Reviews. Microbiology. Oct, 2004 | Pubmed ID: 15378047 Adaptation of Campylobacter Jejuni NCTC11168 to High-level Colonization of the Avian Gastrointestinal Tract Infection and Immunity. Jul, 2004 | Pubmed ID: 15213117 The Yersiniae--a Model Genus to Study the Rapid Evolution of Bacterial Pathogens Nature Reviews. Microbiology. Oct, 2003 | Pubmed ID: 15040180 Genes to Genetic Immunization: Identification of Bacterial Vaccine Candidates Methods (San Diego, Calif.). Nov, 2003 | Pubmed ID: 14511951 Application of DNA Microarrays to Study the Evolutionary Genomics of Yersinia Pestis and Yersinia Pseudotuberculosis Genome Research. Sep, 2003 | Pubmed ID: 12952873 Campylobacter--a Tale of Two Protein Glycosylation Systems Trends in Microbiology. May, 2003 | Pubmed ID: 12781527 Signature-tagged Mutagenesis of Yersinia Pestis Advances in Experimental Medicine and Biology. 2003 | Pubmed ID: 12756725 Microarrays for Bacterial Pathogens - Hope or Hype? Comparative and Functional Genomics. 2002 | Pubmed ID: 18629265 Microarray Analysis of Campylobacter Jejuni: to the Guts of the Problem! Comparative and Functional Genomics. 2002 | Pubmed ID: 18629262 N-linked Glycosylation in Campylobacter Jejuni and Its Functional Transfer into E. Coli Science (New York, N.Y.). Nov, 2002 | Pubmed ID: 12459590 Deciphering Tsetse's Secret Partner Nature Genetics. Nov, 2002 | Pubmed ID: 12410225 Structural Characterization of Lipo-oligosaccharide (LOS) from Yersinia Pestis: Regulation of LOS Structure by the PhoPQ System Molecular Microbiology. Jun, 2002 | Pubmed ID: 12067350 Helicobacter Pylori Adherence to Gastric Epithelial Cells: a Role for Non-adhesin Virulence Genes Journal of Medical Microbiology. Jun, 2002 | Pubmed ID: 12018657 Identification of N-acetylgalactosamine-containing Glycoproteins PEB3 and CgpA in Campylobacter Jejuni Molecular Microbiology. Jan, 2002 | Pubmed ID: 11985725 A Novel Paralogous Gene Family Involved in Phase-variable Flagella-mediated Motility in Campylobacter Jejuni Microbiology (Reading, England). Feb, 2002 | Pubmed ID: 11832511 Bağırsak Epitel Hücreleri Of Enterik Bakteriyel Invasion Neveda Naz1, Dominic C. Mills1, Brendan W. Wren1, Nick Dorrell1 1Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine JoVE 50741 Immunologia e infezioni
Bağırsak Epitel Hücreleri Of Enterik Bakteriyel Invasion Neveda Naz1, Dominic C. Mills1, Brendan W. Wren1, Nick Dorrell1 1Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine JoVE 50741 Immunologia e infezioni