Brian Seed Center for Computational and Integrative Biology Massachusetts General Hospital Biography Publications Institution JoVE Articles Brian Seed has not added a biography. If you are Brian Seed and would like to personalize this page please email our Author Liaison for assistance. Publications Enhanced Tim3 Activity Improves Survival After Influenza Infection Journal of Immunology (Baltimore, Md. : 1950). Sep, 2012 | Pubmed ID: 22875804 STAT6 Phosphorylation Inhibitors Block Eotaxin-3 Secretion in Bronchial Epithelial Cells Bioorganic & Medicinal Chemistry. Jan, 2012 | Pubmed ID: 22217933 PrimerBank: a PCR Primer Database for Quantitative Gene Expression Analysis, 2012 Update Nucleic Acids Research. Jan, 2012 | Pubmed ID: 22086960 Phosphoprotein Associated with Glycosphingolipid-enriched Microdomains Differentially Modulates SRC Kinase Activity in Brain Maturation PloS One. 2011 | Pubmed ID: 21915273 C-aryl Glucosides Substituted at the 4'-position As Potent and Selective Renal Sodium-dependent Glucose Co-transporter 2 (SGLT2) Inhibitors for the Treatment of Type 2 Diabetes Bioorganic & Medicinal Chemistry Letters. Aug, 2011 | Pubmed ID: 21737266 EGT1442, a Potent and Selective SGLT2 Inhibitor, Attenuates Blood Glucose and HbA(1c) Levels in Db/db Mice and Prolongs the Survival of Stroke-prone Rats Pharmacological Research : the Official Journal of the Italian Pharmacological Society. Apr, 2011 | Pubmed ID: 21215314 The Transcription Factor MafB Antagonizes Antiviral Responses by Blocking Recruitment of Coactivators to the Transcription Factor IRF3 Nature Immunology. Aug, 2010 | Pubmed ID: 20581830 Ortho-Substituted C-aryl Glucosides As Highly Potent and Selective Renal Sodium-dependent Glucose Co-transporter 2 (SGLT2) Inhibitors Bioorganic & Medicinal Chemistry. Jun, 2010 | Pubmed ID: 20576578 Mice Lacking Dok-1, Dok-2, and Dok-3 Succumb to Aggressive Histiocytic Sarcoma Laboratory Investigation; a Journal of Technical Methods and Pathology. Sep, 2010 | Pubmed ID: 20548287 Activating WASP Mutations Associated with X-linked Neutropenia Result in Enhanced Actin Polymerization, Altered Cytoskeletal Responses, and Genomic Instability in Lymphocytes The Journal of Experimental Medicine. Jun, 2010 | Pubmed ID: 20513746 Conformationally Constrained Spiro C-arylglucosides As Potent and Selective Renal Sodium-dependent Glucose Co-transporter 2 (SGLT2) Inhibitors ChemMedChem. Jun, 2010 | Pubmed ID: 20414917 Host-encoded Reporters for the Detection and Purification of Multiple Enveloped Viruses Journal of Virological Methods. Aug, 2010 | Pubmed ID: 20399809 Fluorosomes: a Convenient New Reagent to Detect and Block Multivalent and Complex Receptor-ligand Interactions FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2010 | Pubmed ID: 20056716 PrimerBank: a Resource of Human and Mouse PCR Primer Pairs for Gene Expression Detection and Quantification Nucleic Acids Research. Jan, 2010 | Pubmed ID: 19906719 Exploration of O-spiroketal C-arylglucosides As Novel and Selective Renal Sodium-dependent Glucose Co-transporter 2 (SGLT2) Inhibitors Bioorganic & Medicinal Chemistry Letters. Dec, 2009 | Pubmed ID: 19896374 O-Spiro C-aryl Glucosides As Novel Sodium-dependent Glucose Co-transporter 2 (SGLT2) Inhibitors Bioorganic & Medicinal Chemistry Letters. Oct, 2009 | Pubmed ID: 19700318 Modulation of Allergen-specific T-lymphocyte Function by Virus-like Particles Decorated with HLA Class II Molecules The Journal of Allergy and Clinical Immunology. Jul, 2009 | Pubmed ID: 19500826 Lack of Lymphatic Vessel Phenotype in LYVE-1/CD44 Double Knockout Mice Journal of Cellular Physiology. May, 2009 | Pubmed ID: 19170073 A Comprehensive Collection of Experimentally Validated Primers for Polymerase Chain Reaction Quantitation of Murine Transcript Abundance BMC Genomics. 2008 | Pubmed ID: 19108745 Quantitation of Autophagy by Luciferase Release Assay Autophagy. Aug, 2008 | Pubmed ID: 18641457 Spinophilin and the Immune Synapse The Journal of Cell Biology. Apr, 2008 | Pubmed ID: 18411314 A Pathway Sensor for Genome-wide Screens of Intracellular Proteolytic Cleavage Genome Biology. 2008 | Pubmed ID: 18387192 A Novel Sorting Nexin Modulates Endocytic Trafficking and Alpha-secretase Cleavage of the Amyloid Precursor Protein The Journal of Biological Chemistry. May, 2008 | Pubmed ID: 18353773 Molecular and Functional Analysis of the Antigen Receptor of Art V 1-specific Helper T Lymphocytes The Journal of Allergy and Clinical Immunology. Jan, 2008 | Pubmed ID: 18037161 General Strategy for Decoration of Enveloped Viruses with Functionally Active Lipid-modified Cytokines Journal of Virology. Aug, 2007 | Pubmed ID: 17537846 ABCA3 Inactivation in Mice Causes Respiratory Failure, Loss of Pulmonary Surfactant, and Depletion of Lung Phosphatidylglycerol Journal of Lipid Research. Mar, 2007 | Pubmed ID: 17142808 Direct Stimulation of T Lymphocytes by Immunosomes: Virus-like Particles Decorated with T Cell Receptor/CD3 Ligands Plus Costimulatory Molecules Proceedings of the National Academy of Sciences of the United States of America. Aug, 2006 | Pubmed ID: 16924110 A Sequence-oriented Comparison of Gene Expression Measurements Across Different Hybridization-based Technologies Nature Biotechnology. Jul, 2006 | Pubmed ID: 16823376 CARMA1 is Critical for the Development of Allergic Airway Inflammation in a Murine Model of Asthma Journal of Immunology (Baltimore, Md. : 1950). Jun, 2006 | Pubmed ID: 16751370 Expression Cloning Screen for Modifiers of Amyloid Precursor Protein Shedding International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience. Apr-May, 2006 | Pubmed ID: 16446073 B Cell Maturation Antigen, the Receptor for a Proliferation-inducing Ligand and B Cell-activating Factor of the TNF Family, Induces Antigen Presentation in B Cells Journal of Immunology (Baltimore, Md. : 1950). Sep, 2005 | Pubmed ID: 16116167 Large-scale Screens for CDNAs with in Vivo Activity Novartis Foundation Symposium. 2005 | Pubmed ID: 15999809 PDZ Domains and the Politics of Polarity in Lymphocytes Immunity. Jun, 2005 | Pubmed ID: 15963778 Identification of Eosinophil Lineage-committed Progenitors in the Murine Bone Marrow The Journal of Experimental Medicine. Jun, 2005 | Pubmed ID: 15955840 Differential Transplantability of Tumor-associated Stromal Cells Cancer Research. Sep, 2004 | Pubmed ID: 15342367 The Knockout Mouse Project Nature Genetics. Sep, 2004 | Pubmed ID: 15340423 Discs Large (Dlg1) Complexes in Lymphocyte Activation The Journal of Cell Biology. Jul, 2004 | Pubmed ID: 15263016 The Scaffold Protein CNK1 Interacts with the Tumor Suppressor RASSF1A and Augments RASSF1A-induced Cell Death The Journal of Biological Chemistry. Jul, 2004 | Pubmed ID: 15075335 Epstein-Barr Virus Latent Infection Membrane Protein 1 TRAF-binding Site Induces NIK/IKK Alpha-dependent Noncanonical NF-kappaB Activation Proceedings of the National Academy of Sciences of the United States of America. Jan, 2004 | Pubmed ID: 14691250 A PCR Primer Bank for Quantitative Gene Expression Analysis Nucleic Acids Research. Dec, 2003 | Pubmed ID: 14654707 The Cell Adhesion Protein P-selectin Glycoprotein Ligand-1 is a Substrate for the Aspartyl Protease BACE1 The Journal of Biological Chemistry. Dec, 2003 | Pubmed ID: 14507929 Dynamic Imaging of Collagen and Its Modulation in Tumors in Vivo Using Second-harmonic Generation Nature Medicine. Jun, 2003 | Pubmed ID: 12754503 Selection of Oligonucleotide Probes for Protein Coding Sequences Bioinformatics (Oxford, England). May, 2003 | Pubmed ID: 12724288 Site-specific Gene Targeting in Mouse Embryonic Stem Cells with Intact Bacterial Artificial Chromosomes Nature Biotechnology. Apr, 2003 | Pubmed ID: 12627171 Identification of a Novel Ras-regulated Proapoptotic Pathway Current Biology : CB. Feb, 2002 | Pubmed ID: 11864565 İfade Klonlama tarafından Grb2 Sinyal Kompleksi Eğitim için bir Yüksek içerik Görüntüleme İş Akışı Jamie Freeman1, Janos Kriston-Vizi1, Brian Seed2, Robin Ketteler1 1MRC LMCB, University College London, 2Center for Computational and Integrative Biology, Massachusetts General Hospital JoVE 4382 Biologia
İfade Klonlama tarafından Grb2 Sinyal Kompleksi Eğitim için bir Yüksek içerik Görüntüleme İş Akışı Jamie Freeman1, Janos Kriston-Vizi1, Brian Seed2, Robin Ketteler1 1MRC LMCB, University College London, 2Center for Computational and Integrative Biology, Massachusetts General Hospital JoVE 4382 Biologia