Canhui Li Programme in Molecular Structure and Function Hospital for Sick Children Biography Publications Institution JoVE Articles Canhui Li has not added a biography. If you are Canhui Li and would like to personalize this page please email our Author Liaison for assistance. Publications VX-809 and Related Corrector Compounds Exhibit Secondary Activity Stabilizing Active F508del-CFTR After Its Partial Rescue to the Cell Surface Chemistry & Biology. May, 2014 | Pubmed ID: 24726831 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Potentiator VX-770 (ivacaftor) Opens the Defective Channel Gate of Mutant CFTR in a Phosphorylation-dependent but ATP-independent Manner The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 22942289 Synthesis and Properties of Molecular Probes for the Rescue Site on Mutant Cystic Fibrosis Transmembrane Conductance Regulator Journal of Medicinal Chemistry. Dec, 2011 | Pubmed ID: 22074181 Structural Basis for Alginate Secretion Across the Bacterial Outer Membrane Proceedings of the National Academy of Sciences of the United States of America. Aug, 2011 | Pubmed ID: 21778407 A Small-molecule Modulator Interacts Directly with DeltaPhe508-CFTR to Modify Its ATPase Activity and Conformational Stability Molecular Pharmacology. Jun, 2009 | Pubmed ID: 19339490 Direct Interaction of a Small-molecule Modulator with G551D-CFTR, a Cystic Fibrosis-causing Mutation Associated with Severe Disease The Biochemical Journal. Feb, 2009 | Pubmed ID: 18945216 Evidence for a Superoxide Permeability Pathway in Endosomal Membranes Molecular and Cellular Biology. Jun, 2008 | Pubmed ID: 18378695 Probing Structure-function Relationships and Gating Mechanisms in the CorA Mg2+ Transport System The Journal of Biological Chemistry. Apr, 2008 | Pubmed ID: 18276588 The Intact CFTR Protein Mediates ATPase Rather Than Adenylate Kinase Activity The Biochemical Journal. Jun, 2008 | Pubmed ID: 18241200 Nucleotides Bind to the C-terminus of ClC-5 The Biochemical Journal. Sep, 2006 | Pubmed ID: 16686597 Evaluation of the Membrane-spanning Domain of ClC-2 The Biochemical Journal. Jun, 2006 | Pubmed ID: 16526942 Determination of CFTR Chloride Channel Activity and Pharmacology Using Radiotracer Flux Methods Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. Aug, 2004 | Pubmed ID: 15463942 The Patch-clamp and Planar Lipid Bilayer Techniques: Powerful and Versatile Tools to Investigate the CFTR Cl- Channel Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. Aug, 2004 | Pubmed ID: 15463939 Methods to Study CFTR Protein in Vitro Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. Aug, 2004 | Pubmed ID: 15463933 Phosphorylation-induced Conformational Changes of Cystic Fibrosis Transmembrane Conductance Regulator Monitored by Attenuated Total Reflection-Fourier Transform IR Spectroscopy and Fluorescence Spectroscopy The Journal of Biological Chemistry. Feb, 2004 | Pubmed ID: 14660584 Stable Dimeric Assembly of the Second Membrane-spanning Domain of CFTR (cystic Fibrosis Transmembrane Conductance Regulator) Reconstitutes a Chloride-selective Pore The Biochemical Journal. Nov, 2003 | Pubmed ID: 12892562 CFTR Directly Mediates Nucleotide-regulated Glutathione Flux The EMBO Journal. May, 2003 | Pubmed ID: 12727866 Studies of the Molecular Basis for Cystic Fibrosis Using Purified Reconstituted CFTR Protein Methods in Molecular Medicine. 2002 | Pubmed ID: 11917519 Reconstitution fonctionnelle et Activité du Chan mesures de type sauvage purifiée et Mutant protéine CFTR Paul D. W. Eckford1, Canhui Li1, Christine E. Bear1,2,3 1Programme in Molecular Structure and Function, Hospital for Sick Children, 2Department of Biochemistry, University of Toronto, 3Department of Physiology, University of Toronto JoVE 52427 Biologia
Reconstitution fonctionnelle et Activité du Chan mesures de type sauvage purifiée et Mutant protéine CFTR Paul D. W. Eckford1, Canhui Li1, Christine E. Bear1,2,3 1Programme in Molecular Structure and Function, Hospital for Sick Children, 2Department of Biochemistry, University of Toronto, 3Department of Physiology, University of Toronto JoVE 52427 Biologia