Caroline A. Owen Division of Pulmonary and Critical Care Medicine Brigham and Women's Hospital - Harvard Medical School Biography Publications Institution JoVE Articles Caroline A. Owen has not added a biography. If you are Caroline A. Owen and would like to personalize this page please email our Author Liaison for assistance. Publications A Novel Nonhuman Primate Model of Cigarette Smoke-Induced Airway Disease The American Journal of Pathology. Dec, 2014 | Pubmed ID: 25542772 Folliculin Regulates Cell-cell Adhesion, AMPK, and MTORC1 in a Cell-type-specific Manner in Lung-derived Cells Physiological Reports. Aug, 2014 | Pubmed ID: 25121506 Mitophagy-dependent Necroptosis Contributes to the Pathogenesis of COPD The Journal of Clinical Investigation. Sep, 2014 | Pubmed ID: 25083992 ADAM9 is a Novel Product of Polymorphonuclear Neutrophils: Regulation of Expression and Contributions to Extracellular Matrix Protein Degradation During Acute Lung Injury Journal of Immunology (Baltimore, Md. : 1950). Sep, 2014 | Pubmed ID: 25063875 Effects of Sex Hormones on Bronchial Reactivity During the Menstrual Cycle BMC Pulmonary Medicine. 2014 | Pubmed ID: 24984749 Idiopathic Pulmonary Fibrosis and Coronary Artery Disease Multidisciplinary Respiratory Medicine. 2014 | Pubmed ID: 24976970 Mononuclear Phagocytes and Airway Epithelial Cells: Novel Sources of Matrix Metalloproteinase-8 (MMP-8) in Patients with Idiopathic Pulmonary Fibrosis PloS One. 2014 | Pubmed ID: 24828408 Functional Characterization of Polymorphisms in the Peptidase Inhibitor 3 (elafin) Gene and Validation of Their Contribution to Risk of Acute Respiratory Distress Syndrome American Journal of Respiratory Cell and Molecular Biology. Aug, 2014 | Pubmed ID: 24617927 Rapid Lung Function Decline in Smokers is a Risk Factor for COPD and is Attenuated by Angiotensin-converting Enzyme Inhibitor Use Chest. Apr, 2014 | Pubmed ID: 24008986 Comparison of Arterial and Venous Blood Biomarker Levels in Chronic Obstructive Pulmonary Disease F1000Research. 2013 | Pubmed ID: 24555057 The Club Cell and Its Protein, CC16: Time to Shine The Lancet. Respiratory Medicine. Dec, 2013 | Pubmed ID: 24461745 Histone Deacetylase 6-mediated Selective Autophagy Regulates COPD-associated Cilia Dysfunction The Journal of Clinical Investigation. Dec, 2013 | Pubmed ID: 24200693 Adam8 Limits the Development of Allergic Airway Inflammation in Mice Journal of Immunology (Baltimore, Md. : 1950). Jun, 2013 | Pubmed ID: 23670189 Adipose-derived Stem Cells Weigh in As Novel Therapeutics for Acute Lung Injury Stem Cell Research & Therapy. 2013 | Pubmed ID: 23510703 Profibrotic Activities for Matrix Metalloproteinase-8 During Bleomycin-mediated Lung Injury Journal of Immunology (Baltimore, Md. : 1950). Apr, 2013 | Pubmed ID: 23487425 The Role of Systemic Inflammatory Biomarkers to Predict Mortality in Chronic Obstructive Pulmonary Disease Expert Review of Respiratory Medicine. Feb, 2013 | Pubmed ID: 23362815 Selenoprotein N Deficiency in Mice is Associated with Abnormal Lung Development FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Apr, 2013 | Pubmed ID: 23325319 Inflammation in COPD: Implications for Management The American Journal of Medicine. Dec, 2012 | Pubmed ID: 23164484 Interleukin-18: the Master Regulator Driving Destructive and Remodeling Processes in the Lungs of Patients with Chronic Obstructive Pulmonary Disease? American Journal of Respiratory and Critical Care Medicine. Jun, 2012 | Pubmed ID: 22661518 Genetically Manipulated Mouse Models of Lung Disease: Potential and Pitfalls American Journal of Physiology. Lung Cellular and Molecular Physiology. Dec, 2011 | Pubmed ID: 22198907 Polymorphonuclear Neutrophils Move into the Fast Lane in Chronic Obstructive Pulmonary Disease American Journal of Respiratory and Critical Care Medicine. May, 2011 | Pubmed ID: 21531949 Matrix Metalloproteinases: All the RAGE in the Acute Respiratory Distress Syndrome American Journal of Physiology. Lung Cellular and Molecular Physiology. Apr, 2011 | Pubmed ID: 21296893 Matrix Metalloproteinase-8 Inactivates Macrophage Inflammatory Protein-1 Alpha to Reduce Acute Lung Inflammation and Injury in Mice Journal of Immunology (Baltimore, Md. : 1950). Feb, 2010 | Pubmed ID: 20042585 ADAM8: a New Therapeutic Target for Asthma Expert Opinion on Therapeutic Targets. May, 2009 | Pubmed ID: 19397475 Roles for Proteinases in the Pathogenesis of Chronic Obstructive Pulmonary Disease International Journal of Chronic Obstructive Pulmonary Disease. 2008 | Pubmed ID: 18686734 Leukocyte Cell Surface Proteinases: Regulation of Expression, Functions, and Mechanisms of Surface Localization The International Journal of Biochemistry & Cell Biology. 2008 | Pubmed ID: 18329945 CD8+ T Cells Are Required for Inflammation and Destruction in Cigarette Smoke-induced Emphysema in Mice Journal of Immunology (Baltimore, Md. : 1950). Jun, 2007 | Pubmed ID: 17548647 The Sulfate Groups of Chondroitin Sulfate- and Heparan Sulfate-containing Proteoglycans in Neutrophil Plasma Membranes Are Novel Binding Sites for Human Leukocyte Elastase and Cathepsin G The Journal of Biological Chemistry. May, 2007 | Pubmed ID: 17384412 Induction of the Plasminogen Activator System by Mechanical Stimulation of Human Bronchial Epithelial Cells American Journal of Respiratory Cell and Molecular Biology. Dec, 2006 | Pubmed ID: 16794260 Proteinases and Oxidants As Targets in the Treatment of Chronic Obstructive Pulmonary Disease Proceedings of the American Thoracic Society. 2005 | Pubmed ID: 16267366 Membrane-bound Matrix Metalloproteinase-8 on Activated Polymorphonuclear Cells is a Potent, Tissue Inhibitor of Metalloproteinase-resistant Collagenase and Serpinase Journal of Immunology (Baltimore, Md. : 1950). Jun, 2004 | Pubmed ID: 15187163 Neutrophil Elastase in Human Atherosclerotic Plaques: Production by Macrophages Circulation. Jun, 2003 | Pubmed ID: 12771009 Inducible Expression of Tissue Inhibitor of Metalloproteinases-resistant Matrix Metalloproteinase-9 on the Cell Surface of Neutrophils American Journal of Respiratory Cell and Molecular Biology. Sep, 2003 | Pubmed ID: 12663332 ADAM-33 Surfaces As an Asthma Gene The New England Journal of Medicine. Sep, 2002 | Pubmed ID: 12239266 Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice Maria E. Laucho-Contreras1, Katherine L. Taylor1, Ravi Mahadeva2, Steve S. Boukedes3, Caroline A. Owen1,4 1Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital - Harvard Medical School, 2Department of Respiratory Medicine, University of Cambridge - Addenbrooke's Hospital, 3Lung Transplant Program, Brigham and Women's Hospital - Harvard Medical School, 4COPD and IPF Programs, Lovelace Respiratory Research Institute JoVE 52236 Medicina
Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice Maria E. Laucho-Contreras1, Katherine L. Taylor1, Ravi Mahadeva2, Steve S. Boukedes3, Caroline A. Owen1,4 1Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital - Harvard Medical School, 2Department of Respiratory Medicine, University of Cambridge - Addenbrooke's Hospital, 3Lung Transplant Program, Brigham and Women's Hospital - Harvard Medical School, 4COPD and IPF Programs, Lovelace Respiratory Research Institute JoVE 52236 Medicina