Carsten Korth Department of Neuropathology Medical School Düsseldorf Biography Publications Institution JoVE Articles Carsten Korth has not added a biography. If you are Carsten Korth and would like to personalize this page please email our Author Liaison for assistance. Publications Regulation of N-Methyl-D-Aspartate Receptors by Disrupted-in-Schizophrenia-1 Biological Psychiatry. Jul, 2013 | Pubmed ID: 23906531 Revisiting Disrupted in Schizophrenia 1 As a Scaffold Protein Biological Chemistry. Jul, 2013 | Pubmed ID: 23832957 Immunohistochemical Characterization of Novel Monoclonal Antibodies Against the N-terminus of Amyloid β-peptide Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. Sep, 2013 | Pubmed ID: 23829200 Characterization of a Single-chain Variable Fragment Recognizing a Linear Epitope of Aβ: a Biotechnical Tool for Studies on Alzheimer's Disease? PloS One. 2013 | Pubmed ID: 23555792 On the Issue of Transmissibility of Alzheimer Disease: a Critical Review Prion. Nov-Dec, 2012 | Pubmed ID: 23052009 Proteomic, Genomic and Translational Approaches Identify CRMP1 for a Role in Schizophrenia and Its Underlying Traits Human Molecular Genetics. Aug, 2012 | Pubmed ID: 22798627 Identification of Dominant Human Aquaporin 4 T-Cell Epitopes: Observations in Neuromyelitis Optica With Implications for Other Autoimmune DisordershAQP4 T-Cell Epitopes Archives of Neurology. Jul, 2012 | Pubmed ID: 22751933 Human and Rat Brain Lipofuscin Proteome Proteomics. Aug, 2012 | Pubmed ID: 22707227 C-terminal Fragment of N-cadherin Accelerates Synapse Destabilization by Amyloid-β Brain : a Journal of Neurology. Jul, 2012 | Pubmed ID: 22637581 Identification of I137M and Other Mutations That Modulate Incubation Periods for Two Human Prion Strains Journal of Virology. Jun, 2012 | Pubmed ID: 22438549 Aggregated Proteins in Schizophrenia and Other Chronic Mental Diseases: DISC1opathies Prion. Apr-Jun, 2012 | Pubmed ID: 22421208 Cellular Prion Protein Participates in Amyloid-β Transcytosis Across the Blood-brain Barrier Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Apr, 2012 | Pubmed ID: 22293988 Hybrid Compounds: from Simple Combinations to Nanomachines BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. Feb, 2012 | Pubmed ID: 22239618 Molecular Engineering of a Secreted, Highly Homogeneous, and Neurotoxic Aβ Dimer ACS Chemical Neuroscience. May, 2011 | Pubmed ID: 22778868 Rapidly Progressive Alzheimer Disease Archives of Neurology. Sep, 2011 | Pubmed ID: 21911694 Quinpramine Ameliorates Rat Experimental Autoimmune Neuritis and Redistributes MHC Class II Molecules PloS One. 2011 | Pubmed ID: 21698177 Convergence of Two Independent Mental Disease Genes on the Protein Level: Recruitment of Dysbindin to Cell-invasive Disrupted-in-schizophrenia 1 Aggresomes Biological Psychiatry. Oct, 2011 | Pubmed ID: 21531389 Biological Effects and Use of PrPSc- and PrP-specific Antibodies Generated by Immunization with Purified Full-length Native Mouse Prions Journal of Virology. May, 2011 | Pubmed ID: 21345946 No Association Between Genetic Polymorphism at Codon 129 of the Prion Protein Gene and Primary Progressive Multiple Sclerosis Archives of Neurology. Feb, 2011 | Pubmed ID: 21320996 Presenilin-1 but Not Amyloid Precursor Protein Mutations Present in Mouse Models of Alzheimer's Disease Attenuate the Response of Cultured Cells to γ-secretase Modulators Regardless of Their Potency and Structure Journal of Neurochemistry. Feb, 2011 | Pubmed ID: 21091478 Oral Treatment with the D-Enantiomeric Peptide D3 Improves the Pathology and Behavior of Alzheimer's Disease Transgenic Mice ACS Chemical Neuroscience. Sep, 2010 | Pubmed ID: 22778851 Combining Independent Drug Classes into Superior, Synergistically Acting Hybrid Molecules Angewandte Chemie (International Ed. in English). Nov, 2010 | Pubmed ID: 20922735 Human Prion Strain Selection in Transgenic Mice Annals of Neurology. Aug, 2010 | Pubmed ID: 20695008 Quinpramine--a Promising Compound for Treating Immune-mediated Demyelination of the Nervous System Drug News & Perspectives. Jun, 2010 | Pubmed ID: 20603652 Codon 129 Polymorphism and the E200K Mutation Do Not Affect the Cellular Prion Protein Isoform Composition in the Cerebrospinal Fluid from Patients with Creutzfeldt-Jakob Disease The European Journal of Neuroscience. Jun, 2010 | Pubmed ID: 20529115 Disrupted-in-Schizophrenia-1 Expression is Regulated by Beta-site Amyloid Precursor Protein Cleaving Enzyme-1-neuregulin Cascade Proceedings of the National Academy of Sciences of the United States of America. Mar, 2010 | Pubmed ID: 20212127 Pharmacological Prion Protein Silencing Accelerates Central Nervous System Autoimmune Disease Via T Cell Receptor Signalling Brain : a Journal of Neurology. Feb, 2010 | Pubmed ID: 20145049 Microdeletions Within the Hydrophobic Core Region of Cellular Prion Protein Alter Its Topology and Metabolism Biochemical and Biophysical Research Communications. Mar, 2010 | Pubmed ID: 20138835 Structure-activity Relationship of Tocopherol Derivatives Suggesting a Novel Non-antioxidant Mechanism in Antiprion Potency Neuroscience Letters. Jan, 2010 | Pubmed ID: 19945507 DISCopathies: Brain Disorders Related to DISC1 Dysfunction Reviews in the Neurosciences. 2009 | Pubmed ID: 20397618 Understanding the Role of DISC1 in Psychiatric Disease and During Normal Development The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2009 | Pubmed ID: 19828788 Alpha-secretase Mediated Conversion of the Amyloid Precursor Protein Derived Membrane Stub C99 to C83 Limits Abeta Generation Journal of Neurochemistry. Dec, 2009 | Pubmed ID: 19804379 Binding of TCA to the Prion Protein: Mechanism, Implication for Therapy, and Application As Probe for Complex Formation of Bio-macromolecules Journal of Biomolecular Structure & Dynamics. Oct, 2009 | Pubmed ID: 19583442 Oligomer Assembly of the C-terminal DISC1 Domain (640-854) is Controlled by Self-association Motifs and Disease-associated Polymorphism S704C Biochemistry. Aug, 2009 | Pubmed ID: 19583211 Genetic Polymorphism at Codon 129 of the Prion Protein Gene is Not Associated with Multiple Sclerosis Archives of Neurology. Feb, 2009 | Pubmed ID: 19204171 Experimental Neurology. Feb, 2009 | Pubmed ID: 18996373 Complementarity Determining Regions of an Anti-prion Protein ScFv Fragment Orchestrate Conformation Specificity and Antiprion Activity Molecular Immunology. Feb, 2009 | Pubmed ID: 18973947 Genes Contributing to Prion Pathogenesis The Journal of General Virology. Jul, 2008 | Pubmed ID: 18559949 Expansion of the Octarepeat Domain Alters the Misfolding Pathway but Not the Folding Pathway of the Prion Protein Biochemistry. Jun, 2008 | Pubmed ID: 18473442 Insolubility of Disrupted-in-schizophrenia 1 Disrupts Oligomer-dependent Interactions with Nuclear Distribution Element 1 and is Associated with Sporadic Mental Disease The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2008 | Pubmed ID: 18400883 Vaccine Approaches to Prevent and Treat Prion Infection : Progress and Challenges BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. 2008 | Pubmed ID: 18215090 The Use of Conformation-specific Ligands and Assays to Dissect the Molecular Mechanisms of Neurodegenerative Diseases Journal of Neuroscience Research. Aug, 2007 | Pubmed ID: 17497676 A Chimeric Ligand Approach Leading to Potent Antiprion Active Acridine Derivatives: Design, Synthesis, and Biological Investigations Journal of Medicinal Chemistry. Nov, 2006 | Pubmed ID: 17064077 Similar Structure-activity Relationships of Quinoline Derivatives for Antiprion and Antimalarial Effects Journal of Medicinal Chemistry. Aug, 2006 | Pubmed ID: 16913719 Tricyclic Antidepressants, Quinacrine and a Novel, Synthetic Chimera Thereof Clear Prions by Destabilizing Detergent-resistant Membrane Compartments Journal of Neurochemistry. Aug, 2006 | Pubmed ID: 16749906 Emerging Pharmacotherapies for Creutzfeldt-Jakob Disease Archives of Neurology. Apr, 2006 | Pubmed ID: 16606761 Prion Protein Gene Codon 129 Modulates Clinical Course of Neurological Wilson Disease Neuroreport. Apr, 2006 | Pubmed ID: 16543824 The Expanded Octarepeat Domain Selectively Binds Prions and Disrupts Homomeric Prion Protein Interactions The Journal of Biological Chemistry. Feb, 2006 | Pubmed ID: 16352600 Abbreviated Incubation Times for Human Prions in Mice Expressing a Chimeric Mouse-human Prion Protein Transgene Proceedings of the National Academy of Sciences of the United States of America. Apr, 2003 | Pubmed ID: 12684540 Generation of Topically Transgenic Rats by In utero Electroporation and In vivo Bioluminescence Screening Sandra Vomund1, Tamar Sapir2, Orly Reiner2, Maria A. de Souza Silva3, Carsten Korth1 1Department of Neuropathology, Medical School Düsseldorf, 2Department of Molecular Genetics, Weizmann Institute for Science, 3Center of Behavioral Neuroscience, University of Düsseldorf JoVE 50146 Neuroscienze Generation, Purification, and Characterization of Cell-invasive DISC1 Protein Species Verian Bader1, Philipp Ottis1, Martin Pum2, Joseph P. Huston2, Carsten Korth1 1Department of Neuropathology, Medical School Düsseldorf, Germany, 2Center of Behavioral Neuroscience, University of Düsseldorf JoVE 4132 Biologia
Generation of Topically Transgenic Rats by In utero Electroporation and In vivo Bioluminescence Screening Sandra Vomund1, Tamar Sapir2, Orly Reiner2, Maria A. de Souza Silva3, Carsten Korth1 1Department of Neuropathology, Medical School Düsseldorf, 2Department of Molecular Genetics, Weizmann Institute for Science, 3Center of Behavioral Neuroscience, University of Düsseldorf JoVE 50146 Neuroscienze
Generation, Purification, and Characterization of Cell-invasive DISC1 Protein Species Verian Bader1, Philipp Ottis1, Martin Pum2, Joseph P. Huston2, Carsten Korth1 1Department of Neuropathology, Medical School Düsseldorf, Germany, 2Center of Behavioral Neuroscience, University of Düsseldorf JoVE 4132 Biologia