Christopher C. Glembotski

Publications

• Proteomic Analysis of the Cardiac Myocyte Secretome Reveals Extracellular Protective Functions for the ER Stress Response
  Journal of Molecular and Cellular Cardiology. Apr, 2020  |   Pubmed ID: 32339566
• Mesencephalic Astrocyte-derived Neurotrophic Factor is an ER-resident Chaperone That Protects Against Reductive Stress in the Heart
  The Journal of Biological Chemistry. May, 2020  |   Pubmed ID: 32327487
• ATF6 As a Nodal Regulator of Proteostasis in the Heart
  Frontiers in Physiology. 2020  |   Pubmed ID: 32322217
• Reactive Oxygen Species (ROS)-Activatable Prodrug for Selective Activation of ATF6 After Ischemia/Reperfusion Injury
  ACS Medicinal Chemistry Letters. Mar, 2020  |   Pubmed ID: 32184959
• Designing Novel Therapies to Mend Broken Hearts: ATF6 and Cardiac Proteostasis
  Cells. Mar, 2020  |   Pubmed ID: 32138230
• The ER Unfolded Protein Response Effector, ATF6, Reduces Cardiac Fibrosis and Decreases Activation of Cardiac Fibroblasts
  International Journal of Molecular Sciences. Feb, 2020  |   Pubmed ID: 32085622
• Sledgehammer to Scalpel: Broad Challenges to the Heart and Other Tissues Yield Specific Cellular Responses Via Transcriptional Regulation of the ER-Stress Master Regulator ATF6α
  International Journal of Molecular Sciences. Feb, 2020  |   Pubmed ID: 32046286
• Integrating ER and Mitochondrial Proteostasis in the Healthy and Diseased Heart
  Frontiers in Cardiovascular Medicine. 2019  |   Pubmed ID: 32010709
• Physiological Signaling in the Absence of Amidated Peptides
  Proceedings of the National Academy of Sciences of the United States of America. 10, 2019  |   Pubmed ID: 31515450
• Proteostasis and Beyond: ATF6 in Ischemic Disease
  Trends in Molecular Medicine. 06, 2019  |   Pubmed ID: 31078432
• Unfolding the Roles of Mitochondria As Therapeutic Targets for Heart Disease
  Journal of the American College of Cardiology. 04, 2019  |   Pubmed ID: 30975298
• Pharmacologic ATF6 Activation Confers Global Protection in Widespread Disease Models by Reprograming Cellular Proteostasis
  Nature Communications. 01, 2019  |   Pubmed ID: 30643122
• ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the MTORC1 Activator, Rheb
  Circulation Research. 01, 2019  |   Pubmed ID: 30582446
• Expanding the Paracrine Hypothesis of Stem Cell-Mediated Repair in the Heart: When the Unconventional Becomes Conventional
  Circulation Research. 03, 2017  |   Pubmed ID: 28254800
• CaMKIIδ Subtypes Differentially Regulate Infarct Formation Following Ex Vivo Myocardial Ischemia/reperfusion Through NF-κB and TNF-α
  Journal of Molecular and Cellular Cardiology. 02, 2017  |   Pubmed ID: 28077321
• ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the Heart
  Circulation Research. Mar, 2017  |   Pubmed ID: 27932512
• Activation of the ATF6 Branch of the Unfolded Protein Response in Neurons Improves Stroke Outcome
  Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Mar, 2017  |   Pubmed ID: 27217380
• Junctophilin-2 Gene Therapy Rescues Heart Failure by Normalizing RyR2-mediated Ca Release
  International Journal of Cardiology. Dec, 2016  |   Pubmed ID: 27760414
• S100A4 Protects the Myocardium Against Ischemic Stress
  Journal of Molecular and Cellular Cardiology. Nov, 2016  |   Pubmed ID: 27721024
• Breaking Down the COP9 Signalsome in the Heart: How Inactivating a Protein Ubiquitin Ligase Increases Protein Ubiquitylation and Protects the Heart
  Circulation Research. Nov, 2015  |   Pubmed ID: 26541679
• Hrd1 and ER-Associated Protein Degradation, ERAD, Are Critical Elements of the Adaptive ER Stress Response in Cardiac Myocytes
  Circulation Research. Aug, 2015  |   Pubmed ID: 26137860
• Finding the Missing Link Between the Unfolded Protein Response and O-GlcNAcylation in the Heart
  Circulation Research. Aug, 2014  |   Pubmed ID: 25170091
• Roles for ATF6 and the Sarco/endoplasmic Reticulum Protein Quality Control System in the Heart
  Journal of Molecular and Cellular Cardiology. Jun, 2014  |   Pubmed ID: 24140798
• Classic Studies of Cultured Cardiac Myocyte Hypertrophy: Interview with a Transformer
  Circulation Research. Oct, 2013  |   Pubmed ID: 24158575
• Mechanistic Target of Rapamycin Complex 2 Protects the Heart from Ischemic Damage
  Circulation. Nov, 2013  |   Pubmed ID: 24008870
• Pathological Hypertrophy Amelioration by PRAS40-mediated Inhibition of MTORC1
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2013  |   Pubmed ID: 23842089
• Regulation of Cardiac Hypertrophic Signaling by Prolyl Isomerase Pin1
  Circulation Research. Apr, 2013  |   Pubmed ID: 23487407
• ATF6 [corrected] and Thrombospondin 4: the Dynamic Duo of the Adaptive Endoplasmic Reticulum Stress Response
  Circulation Research. Jan, 2013  |   Pubmed ID: 23287452
• New Concepts of Endoplasmic Reticulum Function in the Heart: Programmed to Conserve
  Journal of Molecular and Cellular Cardiology. Feb, 2013  |   Pubmed ID: 23085588
• Roles for the Sarco-/endoplasmic Reticulum in Cardiac Myocyte Contraction, Protein Synthesis, and Protein Quality Control
  Physiology (Bethesda, Md.). Dec, 2012  |   Pubmed ID: 23223628
• Clarifying the Cardiac Proteasome Paradox: Protein Quality Control
  Circulation Research. Aug, 2012  |   Pubmed ID: 22904038
• Limitation of Individual Folding Resources in the ER Leads to Outcomes Distinct from the Unfolded Protein Response
  Journal of Cell Science. Oct, 2012  |   Pubmed ID: 22854046
• Mesencephalic Astrocyte-derived Neurotrophic Factor Protects the Heart from Ischemic Damage and is Selectively Secreted Upon Sarco/endoplasmic Reticulum Calcium Depletion
  The Journal of Biological Chemistry. Jul, 2012  |   Pubmed ID: 22637475
• Protein Disulfide Isomerase-associated 6 is an ATF6-inducible ER Stress Response Protein That Protects Cardiac Myocytes from Ischemia/reperfusion-mediated Cell Death
  Journal of Molecular and Cellular Cardiology. Aug, 2012  |   Pubmed ID: 22609432
• Regulation of MicroRNA Expression in the Heart by the ATF6 Branch of the ER Stress Response
  Journal of Molecular and Cellular Cardiology. May, 2012  |   Pubmed ID: 22326432
• The Cardiokine Story Unfolds: Ischemic Stress-induced Protein Secretion in the Heart
  Trends in Molecular Medicine. Apr, 2011  |   Pubmed ID: 21277256
• Functions for the Cardiomyokine, MANF, in Cardioprotection, Hypertrophy and Heart Failure
  Journal of Molecular and Cellular Cardiology. Oct, 2011  |   Pubmed ID: 20970425
• Pim-1 Kinase Protects Mitochondrial Integrity in Cardiomyocytes
  Circulation Research. Apr, 2010  |   Pubmed ID: 20203306
• Roles for Endoplasmic Reticulum-associated Degradation and the Novel Endoplasmic Reticulum Stress Response Gene Derlin-3 in the Ischemic Heart
  Circulation Research. Feb, 2010  |   Pubmed ID: 19940266
• The ATF6-Met[67]Val Substitution is Associated with Increased Plasma Cholesterol Levels
  Arteriosclerosis, Thrombosis, and Vascular Biology. Sep, 2009  |   Pubmed ID: 19667116
• Ischemia Activates the ATF6 Branch of the Endoplasmic Reticulum Stress Response
  The Journal of Biological Chemistry. Oct, 2009  |   Pubmed ID: 19622751
• LPS-induced Autophagy is Mediated by Oxidative Signaling in Cardiomyocytes and is Associated with Cytoprotection
  American Journal of Physiology. Heart and Circulatory Physiology. Feb, 2009  |   Pubmed ID: 19098111
• Mesencephalic Astrocyte-derived Neurotrophic Factor is an Ischemia-inducible Secreted Endoplasmic Reticulum Stress Response Protein in the Heart
  Circulation Research. Nov, 2008  |   Pubmed ID: 18927462
• Coordination of Growth and Endoplasmic Reticulum Stress Signaling by Regulator of Calcineurin 1 (RCAN1), a Novel ATF6-inducible Gene
  The Journal of Biological Chemistry. May, 2008  |   Pubmed ID: 18319259
• The Role of the Unfolded Protein Response in the Heart
  Journal of Molecular and Cellular Cardiology. Mar, 2008  |   Pubmed ID: 18054039
• Pim-1 Regulates Cardiomyocyte Survival Downstream of Akt
  Nature Medicine. Dec, 2007  |   Pubmed ID: 18037896
• Endoplasmic Reticulum Stress in the Heart
  Circulation Research. Nov, 2007  |   Pubmed ID: 17991891
• Getting a G--RRP on Regulated Exocytosis in the Heart
  The Journal of Cell Biology. Nov, 2007  |   Pubmed ID: 17967951
• Effects of the Isoform-specific Characteristics of ATF6 Alpha and ATF6 Beta on Endoplasmic Reticulum Stress Response Gene Expression and Cell Viability
  The Journal of Biological Chemistry. Aug, 2007  |   Pubmed ID: 17522056
• Activation of the Unfolded Protein Response in Infarcted Mouse Heart and Hypoxic Cultured Cardiac Myocytes
  Circulation Research. Aug, 2006  |   Pubmed ID: 16794188
• Endoplasmic Reticulum Stress Gene Induction and Protection from Ischemia/reperfusion Injury in the Hearts of Transgenic Mice with a Tamoxifen-regulated Form of ATF6
  Circulation Research. May, 2006  |   Pubmed ID: 16601230
• Atrial Natriuretic Peptide Promotes Cardiomyocyte Survival by CGMP-dependent Nuclear Accumulation of Zyxin and Akt
  The Journal of Clinical Investigation. Oct, 2005  |   Pubmed ID: 16200208
• Overexpression of Mitogen-activated Protein Kinase Kinase 6 in the Heart Improves Functional Recovery from Ischemia in Vitro and Protects Against Myocardial Infarction in Vivo
  The Journal of Biological Chemistry. Jan, 2005  |   Pubmed ID: 15492008
• Opposing Roles for ATF6alpha and ATF6beta in Endoplasmic Reticulum Stress Response Gene Induction
  The Journal of Biological Chemistry. May, 2004  |   Pubmed ID: 14973138
• Factor Associated with Neutral Sphingomyelinase Activation and Its Role in Cardiac Cell Death
  Circulation Research. Apr, 2003  |   Pubmed ID: 12637370
• Mimicking Phosphorylation of AlphaB-crystallin on Serine-59 is Necessary and Sufficient to Provide Maximal Protection of Cardiac Myocytes from Apoptosis
  Circulation Research. Feb, 2003  |   Pubmed ID: 12574148
• Expression and Functional Characterization of SCaMPER: a Sphingolipid-modulated Calcium Channel of Cardiomyocytes
  American Journal of Physiology. Cell Physiology. Mar, 2003  |   Pubmed ID: 12421694
• Coordination of ATF6-mediated Transcription and ATF6 Degradation by a Domain That is Shared with the Viral Transcription Factor, VP16
  The Journal of Biological Chemistry. Jun, 2002  |   Pubmed ID: 11909875
• A Role for the P38 Mitogen-activated Protein Kinase Pathway in Myocardial Cell Growth, Sarcomeric Organization, and Cardiac-specific Gene Expression
  The Journal of Cell Biology. Oct, 1997  |   Pubmed ID: 9314533