Christopher N. Boddy Department of Chemistry and Biomolecular Sciences University of Ottawa Biography Publications Institution JoVE Articles Christopher N. Boddy has not added a biography. If you are Christopher N. Boddy and would like to personalize this page please email our Author Liaison for assistance. Publications Sampling Terrestrial Environments for Bacterial Polyketides Molecules (Basel, Switzerland). Apr, 2017 | Pubmed ID: 28468277 Natural Products: Mapping an Amazing Thicket Nature Chemical Biology. Dec, 2016 | Pubmed ID: 27984578 Portable, On-Demand Biomolecular Manufacturing Cell. Sep, 2016 | Pubmed ID: 27662092 Total Biosynthesis of Legionaminic Acid, a Bacterial Sialic Acid Analogue Angewandte Chemie (International Ed. in English). Sep, 2016 | Pubmed ID: 27538580 First-in-class Small Molecule Potentiators of Cancer Virotherapy Scientific Reports. May, 2016 | Pubmed ID: 27226390 The Use of ClusterMine360 for the Analysis of Polyketide and Nonribosomal Peptide Biosynthetic Pathways Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 26831712 Diastereoseletive Transannular Oxa-Conjugate Addition Generates the 2,6-cis-Disubstituted Tetrahydropyran of Neopeltolide The Journal of Organic Chemistry. Jan, 2016 | Pubmed ID: 26675500 Towards a Characterization of the Structural Determinants of Specificity in the Macrocyclizing Thioesterase for Deoxyerythronolide B Biosynthesis Biochimica Et Biophysica Acta. Mar, 2016 | Pubmed ID: 26592346 Polyketide Synthase and Non-ribosomal Peptide Synthetase Thioesterase Selectivity: Logic Gate or a Victim of Fate? Natural Product Reports. Feb, 2016 | Pubmed ID: 25642666 Thermoplasmonic SsDNA Dynamic Release from Gold Nanoparticles Examined with Advanced Fluorescence Microscopy The Journal of Physical Chemistry Letters. Apr, 2015 | Pubmed ID: 26263158 Draft Genome Sequence of Streptomyces Sp. Strain PBH53, Isolated from an Urban Environment Genome Announcements. Jul, 2015 | Pubmed ID: 26227608 Modulation of Antifreeze Activity and the Effect Upon Post-thaw HepG2 Cell Viability After Cryopreservation Cryobiology. Apr, 2015 | Pubmed ID: 25595636 Resorcylic Acid Lactone Biosynthesis Relies on a Stereotolerant Macrocyclizing Thioesterase Organic Letters. Nov, 2014 | Pubmed ID: 25372311 An Evolutionary Model Encompassing Substrate Specificity and Reactivity of Type I Polyketide Synthase Thioesterases Chembiochem : a European Journal of Chemical Biology. Dec, 2014 | Pubmed ID: 25354333 Salvadenosine, a 5'-deoxy-5'-(methylthio) Nucleoside from the Bahamian Tunicate Didemnum Sp The Journal of Organic Chemistry. Nov, 2014 | Pubmed ID: 25284474 Genetic Analysis of the Assimilation of C5-dicarboxylic Acids in Pseudomonas Aeruginosa PAO1 Journal of Bacteriology. Jul, 2014 | Pubmed ID: 24794562 Habitat-specific Type I Polyketide Synthases in Soils and Street Sediments Journal of Industrial Microbiology & Biotechnology. Jan, 2014 | Pubmed ID: 24241933 Bioinformatics Tools for Genome Mining of Polyketide and Non-ribosomal Peptides Journal of Industrial Microbiology & Biotechnology. Feb, 2014 | Pubmed ID: 24174214 Elucidation of Gephyronic Acid Biosynthetic Pathway Revealed Unexpected SAM-dependent Methylations Journal of Natural Products. Dec, 2013 | Pubmed ID: 24298873 The Role of Transcription in Heterologous Expression of Polyketides in Bacterial Hosts Natural Product Reports. Oct, 2013 | Pubmed ID: 24061690 Biosynthesis of Ebelactone A: Isotopic Tracer, Advanced Precursor and Genetic Studies Reveal a Thioesterase-independent Cyclization to Give a Polyketide β-lactone The Journal of Antibiotics. Jul, 2013 | Pubmed ID: 23801186 Autre Facteur Sigma Surexpression Permet L'Expression Hétérologue D'une Voie Biosynthétique Polycétide De Type II Chez Escherichia Coli PloS One. 2013 | Pubmed ID: 23724102 Gene PA2449 is Essential for Glycine Metabolism and Pyocyanin Biosynthesis in Pseudomonas Aeruginosa PAO1 Journal of Bacteriology. May, 2013 | Pubmed ID: 23457254 ClusterMine360: a Database of Microbial PKS/NRPS Biosynthesis Nucleic Acids Research. Jan, 2013 | Pubmed ID: 23104377 Non-canonical Regioisomerizations and a 'Diels-Alderase' Are Likely Essential in the Biosynthesis of Spiculoic Acid A Bioorganic & Medicinal Chemistry Letters. Aug, 2012 | Pubmed ID: 22801647 6-Deoxyerythronolide B Synthase Thioesterase-catalyzed Macrocyclization is Highly Stereoselective Organic Letters. May, 2012 | Pubmed ID: 22519860 Reinvestigation of Coenzyme Q10 Isolation from Sporidiobolus Johnsonii Chemistry & Biodiversity. Jun, 2011 | Pubmed ID: 21674778 Heterologous Expression of the Oxytetracycline Biosynthetic Pathway in Myxococcus Xanthus Applied and Environmental Microbiology. Apr, 2010 | Pubmed ID: 20208031 A Thioesterase from an Iterative Fungal Polyketide Synthase Shows Macrocyclization and Cross Coupling Activity and May Play a Role in Controlling Iterative Cycling Through Product Offloading Biochemistry. Jul, 2009 | Pubmed ID: 19530704 Polyketide Synthase Thioesterases Catalyze Rapid Hydrolysis of Peptidyl Thioesters Bioorganic & Medicinal Chemistry Letters. Mar, 2009 | Pubmed ID: 19188064 Biomimetic Transannular Oxa-conjugate Addition Approach to the 2,6-disubstituted Dihydropyran of Laulimalide Yields an Unprecedented Transannular Oxetane The Journal of Organic Chemistry. Feb, 2009 | Pubmed ID: 19159194 Examining the Role of Hydrogen Bonding Interactions in the Substrate Specificity for the Loading Step of Polyketide Synthase Thioesterase Domains Biochemistry. Nov, 2008 | Pubmed ID: 18850723 Orthogonal Ligation: a Three Piece Assembly of a PNA-peptide-PNA Conjugate Chemical Communications (Cambridge, England). Jun, 2008 | Pubmed ID: 18688310 A New Mechanism for Benzopyrone Formation in Aromatic Polyketide Biosynthesis Journal of the American Chemical Society. Aug, 2007 | Pubmed ID: 17625867 Sialic Acid and N-acyl Sialic Acid Analog Production by Fermentation of Metabolically and Genetically Engineered Escherichia Coli Organic & Biomolecular Chemistry. Jun, 2007 | Pubmed ID: 17551639 The Thioesterase Domain from the Pimaricin and Erythromycin Biosynthetic Pathways Can Catalyze Hydrolysis of Simple Thioester Substrates Bioorganic & Medicinal Chemistry Letters. Jun, 2007 | Pubmed ID: 17428661 Total Biosynthesis of Antitumor Nonribosomal Peptides in Escherichia Coli Nature Chemical Biology. Aug, 2006 | Pubmed ID: 16799553 Sweetening Cyclic Peptide Libraries Chemistry & Biology. Dec, 2004 | Pubmed ID: 15610840 Precursor-directed Biosynthesis of Epothilone in Escherichia Coli Journal of the American Chemical Society. Jun, 2004 | Pubmed ID: 15198579 Understanding Substrate Specificity of Polyketide Synthase Modules by Generating Hybrid Multimodular Synthases The Journal of Biological Chemistry. Oct, 2003 | Pubmed ID: 12923197 Epothilone C Macrolactonization and Hydrolysis Are Catalyzed by the Isolated Thioesterase Domain of Epothilone Polyketide Synthase Journal of the American Chemical Society. Mar, 2003 | Pubmed ID: 12643694 Atropselective Macrocyclization of Diaryl Ether Ring Systems: Application to the Synthesis of Vancomycin Model Systems Journal of the American Chemical Society. Sep, 2002 | Pubmed ID: 12197747 Does CIP Nomenclature Adequately Handle Molecules with Multiple Stereoelements? A Case Study of Vancomycin and Cognates We Would Like to Thank Professor Dieter Hellwinkel for Pointing out to Us the Stereochemical Discrepancies in Our Review6 and Elsewhere in the Literature, and Kurt Mislow for Stimulating and Useful Discussions Angewandte Chemie (International Ed. in English). Feb, 2001 | Pubmed ID: 11241596 Système d'expression multigène médié par l'ARN T7 à ADN polymère induible, pMGX Mohamed I. Hassan*1, Fern R. McSorley*1, Kinya Hotta2, Christopher N. Boddy1 1Department of Chemistry and Biomolecular Sciences, University of Ottawa, 2School of Biosciences, The University of Nottingham Malaysia Campus JoVE 55187 Genetica
Système d'expression multigène médié par l'ARN T7 à ADN polymère induible, pMGX Mohamed I. Hassan*1, Fern R. McSorley*1, Kinya Hotta2, Christopher N. Boddy1 1Department of Chemistry and Biomolecular Sciences, University of Ottawa, 2School of Biosciences, The University of Nottingham Malaysia Campus JoVE 55187 Genetica