Chuan-ju Liu Department of Orthopaedic Surgery & Department of Cell Biology NYU School of Medicine Biography Publications Institution JoVE Articles Chuan-ju LiuProfessor of Orthopaedic Surgery and Cell Biology Dr. Chuanju Liu held a dual appointment as an Assistant Professor from Department of Orthopaedic Surgery and Department of Cell Biology at NYU School of Medicine since 2002, and was promoted to Associate Professor with Tenure and Professor with Tenure in 2007 and 2013, respectively. He is the current Editor-in-Chief of Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders and Rheumatology Research and Review, and serves on a number of Editorial Boards. He is also an active participant in peer review of grant applications to various agencies (NIH, DOD, VA, etc.). His current research focuses on inflammatory and degenerative arthritis, cartilage/bone regeneration, and autoimmune diseases. He has published over 140 papers in prestigious journals, including Science, ARD, EMBO J, and PNAS. He is the recipient of numerous awards, including the ASBMR's Harold M. Frost Award, the Arthritis Foundation's Dorothy W. Goldstein Award, the NIH Career Development Award, the Kappa Delta Award from the ORS and AAOS, the Innovative Research Award from the American College of Rheumatology, and the STAR Award from NIH/NIAMS. Publications Progranulin Promotes Diabetic Fracture Healing in Mice with Type 1 Diabetes Annals of the New York Academy of Sciences. Aug, 2019 | Pubmed ID: 31423598 Fexofenadine Inhibits TNF Signaling Through Targeting to Cytosolic Phospholipase A2 and is Therapeutic Against Inflammatory Arthritis Annals of the Rheumatic Diseases. Jul, 2019 | Pubmed ID: 31302596 Progranulin: A Conductor of Receptors Orchestra, a Chaperone of Lysosomal Enzymes and a Therapeutic Target for Multiple Diseases Cytokine & Growth Factor Reviews. 02, 2019 | Pubmed ID: 30733059 Clinical Application of Teriparatide in Fracture Prevention: A Systematic Review JBJS Reviews. Jan, 2019 | Pubmed ID: 30694878 Targeting Tumor Necrosis Factor Receptors in Ankylosing Spondylitis Annals of the New York Academy of Sciences. Apr, 2019 | Pubmed ID: 30008173 Brain-penetrant Heat Shock Protein Amplifier Arimoclomol Enhances GCase Activity in in Vitro Gaucher Disease Models EBioMedicine. 12, 2018 | Pubmed ID: 30522930 Progranulin Associates with Hexosaminidase A and Ameliorates GM2 Ganglioside Accumulation and Lysosomal Storage in Tay-Sachs Disease Journal of Molecular Medicine (Berlin, Germany). Dec, 2018 | Pubmed ID: 30341570 Establishment of a Modified Collagen-Induced Arthritis Mouse Model to Investigate the Anti-inflammatory Activity of Progranulin in Inflammatory Arthritis Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 29956284 Role of ADAMTS-12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth Factor Arthritis & Rheumatology (Hoboken, N.J.). 11, 2018 | Pubmed ID: 29750395 Molecular Regulations and Therapeutic Targets of Gaucher Disease Cytokine & Growth Factor Reviews. 06, 2018 | Pubmed ID: 29699937 P204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice EBioMedicine. Mar, 2018 | Pubmed ID: 29472103 Chitinase-3-like Protein 1: A Progranulin Downstream Molecule and Potential Biomarker for Gaucher Disease EBioMedicine. Feb, 2018 | Pubmed ID: 29396296 Multifunctional Molecule ERp57: From Cancer to Neurodegenerative Diseases Pharmacology & Therapeutics. 01, 2018 | Pubmed ID: 28723413 Progranulin: A Key Player in Autoimmune Diseases Cytokine. 01, 2018 | Pubmed ID: 27527809 Progranulin Derivative Atsttrin Protects Against Early Osteoarthritis in Mouse and Rat Models Arthritis Research & Therapy. Dec, 2017 | Pubmed ID: 29258611 Progranulin Acts As a Shared Chaperone and Regulates Multiple Lysosomal Enzymes Genes & Diseases. Sep, 2017 | Pubmed ID: 28944282 Foxo4- and Stat3-dependent IL-10 Production by Progranulin in Regulatory T Cells Restrains Inflammatory Arthritis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 04, 2017 | Pubmed ID: 28011648 Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease EBioMedicine. Nov, 2016 | Pubmed ID: 27789271 Association Between Progranulin and Gaucher Disease EBioMedicine. Sep, 2016 | Pubmed ID: 27515686 Review: Novel Insights Into Tumor Necrosis Factor Receptor, Death Receptor 3, and Progranulin Pathways in Arthritis and Bone Remodeling Arthritis & Rheumatology (Hoboken, N.J.). 12, 2016 | Pubmed ID: 27428882 Extracellular Matrix Protein 1, a Direct Targeting Molecule of Parathyroid Hormone-related Peptide, Negatively Regulates Chondrogenesis and Endochondral Ossification Via Associating with Progranulin Growth Factor FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 08, 2016 | Pubmed ID: 27075243 Progranulin Suppresses Titanium Particle Induced Inflammatory Osteolysis by Targeting TNFα Signaling Scientific Reports. Feb, 2016 | Pubmed ID: 26864916 Does Progranulin Account for the Opposite Effects of Etanercept and Infliximab/adalimumab in Osteoarthritis?: Comment on Olson Et Al.: "Therapeutic Opportunities to Prevent Post-Traumatic Arthritis: Lessons From the Natural History of Arthritis After Articular Fracture" Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Jan, 2016 | Pubmed ID: 26519939 Progranulin Knockout Accelerates Intervertebral Disc Degeneration in Aging Mice Scientific Reports. Mar, 2015 | Pubmed ID: 25777988 Overexpression of ADAMTS-7 Leads to Accelerated Initiation and Progression of Collagen-induced Arthritis in Mice Molecular and Cellular Biochemistry. Jun, 2015 | Pubmed ID: 25742929 Progranulin Protects Against Osteoarthritis Through Interacting with TNF-α and β-Catenin Signalling Annals of the Rheumatic Diseases. Dec, 2015 | Pubmed ID: 25169730 Progranulin Facilitates Conversion and Function of Regulatory T Cells Under Inflammatory Conditions PloS One. 2014 | Pubmed ID: 25393765 PGRN Protects Against Colitis Progression in Mice in an IL-10 and TNFR2 Dependent Manner Scientific Reports. Nov, 2014 | Pubmed ID: 25387791 ADAMTS-18: a Metalloproteinase with Multiple Functions Frontiers in Bioscience (Landmark Edition). Jun, 2014 | Pubmed ID: 24896365 Three TNFR-binding Domains of PGRN Act Independently in Inhibition of TNF-alpha Binding and Activity Frontiers in Bioscience (Landmark Edition). Jun, 2014 | Pubmed ID: 24896343 Progranulin Inhibition of TNFα Immunology and Cell Biology. Feb, 2014 | Pubmed ID: 24518982 Progranulin Directly Binds to the CRD2 and CRD3 of TNFR Extracellular Domains FEBS Letters. Nov, 2013 | Pubmed ID: 24070898 ADAMTS-7 Forms a Positive Feedback Loop with TNF-α in the Pathogenesis of Osteoarthritis Annals of the Rheumatic Diseases. Dec, 2013 | Pubmed ID: 23928557 The Promotion of Bone Healing by Progranulin, a Downstream Molecule of BMP-2, Through Interacting with TNF/TNFR Signaling Biomaterials. Sep, 2013 | Pubmed ID: 23746860 Progranulin Deficiency Exaggerates, Whereas Progranulin-derived Atsttrin Attenuates, Severity of Dermatitis in Mice FEBS Letters. Jun, 2013 | Pubmed ID: 23669357 Prevention of Atrophic Nonunion by the Systemic Administration of Parathyroid Hormone (PTH 1-34) in an Experimental Animal Model Journal of Orthopaedic Trauma. Dec, 2012 | Pubmed ID: 22932751 Progranulin: 한 성장 인자, 소설 TNFR Ligand와 마약 대상 Pharmacology & Therapeutics. Jan, 2012 | Pubmed ID: 22008260 GEP MyoD 부정적인 피드백 루프를 구성 하 고 제어 골격 근육 분화에 소설 중재자 역할 Cellular and Molecular Life Sciences : CMLS. Dec, 2011 | Pubmed ID: 22179841 Progranulin: 류 마티스 관절염을 위한 유망한 치료 대상 FEBS Letters. Dec, 2011 | Pubmed ID: 21550343 성장 인자 Progranulin TNF 수용 체에 바인딩하고 생쥐에서 염증 성 관절염에 대 한 치료입니다 Science (New York, N.Y.). Apr, 2011 | Pubmed ID: 21393509 연골 Oligomeric 매트릭스 단백질 뼈 전체적 단백질-2와 상호 작용 하 여 혈관 평활 근 석 회화를 억제 한다 Circulation Research. Apr, 2011 | Pubmed ID: 21350216 관절염에서 Adamtss의 역할입니다 Protein & Cell. Jan, 2010 | Pubmed ID: 21203996 GEP, 로컬 성장 인자는 Odontogenesis 및 Amelogenesis에 대 한 중요 합니다 International Journal of Biological Sciences. 2010 | Pubmed ID: 21152114 매트릭스 Metalloproteinases는 연결 하 고 뼈 전체적 단백질-2 체 외를 쪼개 다 Hypertrophic 골절 앞장서서 조직에 높은 됩니다 Journal of Orthopaedic Trauma. Sep, 2010 | Pubmed ID: 20736794 연골 Oligomeric 매트릭스 단백질 및 세포 외 기질 단백질 1 간의 상호 작용 Endochondral 뼈 성장을 중재 Matrix Biology : Journal of the International Society for Matrix Biology. May, 2010 | Pubmed ID: 20138147 Granulin Epithelin 전조: 뼈 Morphogenic 단백질 2을 유도할 수 있는 성장 요인 Erk1/2 신호 및 Chondrogenesis에 JunB 전사 인자를 활성화 하는 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2010 | Pubmed ID: 20124436 연골 Oligomeric 매트릭스 단백질 Alpha(7)beta(1) Integrin 상호 작용 하 여 혈관 부드러운 근육 세포의 수축 성 표현 형을 유지 한다 Circulation Research. Feb, 2010 | Pubmed ID: 20019333 BMP-7 및 여러 BMP 길 항 제에 대 한 표현의 수준을 과감히 골절에 필수적인 역할을 재생할 수 있습니다: 파일럿 연구 Clinical Orthopaedics and Related Research. Dec, 2009 | Pubmed ID: 19597895 ADAMTS-7, PTHrP의 직접적인 대상인 부정적인 연관 및 GEP 성장 인자를 비활성화 하 여 Endochondral 뼈 성장 조절 Molecular and Cellular Biology. Aug, 2009 | Pubmed ID: 19487464 Skeletogenesis에서 Micrornas입니다 Frontiers in Bioscience : a Journal and Virtual Library. 2009 | Pubmed ID: 19273234 미르-199a, 뼈 Morphogenic 단백질 2 응답 MicroRNA Chondrogenesis Smad1을 직접 타겟팅을 통해 조절 합니다 The Journal of Biological Chemistry. Apr, 2009 | Pubmed ID: 19251704 ADAMTS-7 동맥 풍선 손상 쥐에에서 혈관 부드러운 근육 세포 마이그레이션과 Neointima 형성을 중재 합니다 Circulation Research. Mar, 2009 | Pubmed ID: 19168437 관절염의 병 인에 ADAMTS 7 ADAMTS 12의 역할 Nature Clinical Practice. Rheumatology. Jan, 2009 | Pubmed ID: 19098927 P204, P 200 가족 단백질, 세포 증식 및 분화의 다기능 레 귤 레이 터로 Cytokine & Growth Factor Reviews. Oct-Dec, 2008 | Pubmed ID: 19027346 Inhibition of ADAMTS-7 and ADAMTS-12 Degradation of Cartilage Oligomeric Matrix Protein by Alpha-2-macroglobulin Osteoarthritis and Cartilage. Nov, 2008 | Pubmed ID: 18485748 P204 단백질 Id 나선 루프 나선 단백질에 의해 코어 바인딩 요소 알파 1 중재 Osteogenic 차별화의 저해를 극복 했다 Molecular Biology of the Cell. May, 2008 | Pubmed ID: 18287524 Rbap48는 유형의 인간 유 두 종 바이러스 16 자 궁 경부 암에 변형 활동을 제어 하는 중요 한 중재자입니다 The Journal of Biological Chemistry. Sep, 2007 | Pubmed ID: 17616526 IFI16 Inhibits Tumorigenicity and Cell Proliferation of Bone and Cartilage Tumor Cells Frontiers in Bioscience : a Journal and Virtual Library. 2007 | Pubmed ID: 17569615 Sox9, Sox5, 및 Sox6 전사 인자 및 CBP/p300 Coactivators에 의해 연골 Oligomeric 매트릭스 단백질의 Transcriptional 활성화 Frontiers in Bioscience : a Journal and Virtual Library. 2007 | Pubmed ID: 17485346 Retinoblastoma 단백질 P204 단백질의 활동 증가 Cbfa1 전사 인자에 연결 하는 골의 필수적인 중개자 이다 The Journal of Biological Chemistry. Jun, 2007 | Pubmed ID: 17439944 단백질 단백질 상호 작용 및 인간 유기 용 질 전송의 멤브레인 지역화 American Journal of Physiology. Gastrointestinal and Liver Physiology. Jun, 2007 | Pubmed ID: 17332473 연골 Oligomeric 매트릭스 단백질 Granulin Epithelin 전조 (GEP)에 연결 하 고 Potentiates GEP 자극 Chondrocyte 확산 The Journal of Biological Chemistry. Apr, 2007 | Pubmed ID: 17307734 ADAMTS-12에 연결 하 고 연골 Oligomeric 매트릭스 단백질을 저하 됩니다 The Journal of Biological Chemistry. Jun, 2006 | Pubmed ID: 16611630 ADAMTS-7: 직접에 바인딩하고 연골 Oligomeric 매트릭스 단백질을 저하 하는 Metalloproteinase FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2006 | Pubmed ID: 16585064 P204 단백질 Id 단백질 심장 Myocytes 꺾고 P19 Murine Embryonal 암 세포의 분화의 저해를 극복 했다 The Journal of Biological Chemistry. May, 2006 | Pubmed ID: 16556596 P204는 박동 심장 Myocytes P19 Murine Embryonal 암 세포의 분화에 대 한 필요:의 식은 심장 Gata4, Nkx2.5, 및 Tbx5 단백질에 의해 활성화 됩니다 The Journal of Biological Chemistry. May, 2006 | Pubmed ID: 16556595 총 엉덩이 무릎 관절 교체에 따라 Periprosthetic 감염의 표식으로 혈 청 인터 루 킨-6 The Journal of Bone and Joint Surgery. American Volume. Sep, 2005 | Pubmed ID: 16140805 인터페론을 유도할 수 있는 P204 단백질 Cbfa1의 Transcriptional Coactivator 고 Osteoblast 차별화 향상 됩니다 The Journal of Biological Chemistry. Jan, 2005 | Pubmed ID: 15557274 백혈병/림프 종 관련 요소를 없음 포함 하는 도메인 Transcriptional 진압, 히스톤 Deacetylase-1 상호 작용 하 고 연골 Oligomeric 매트릭스 단백질 유전자 발현 및 Chondrogenesis를 억제 한다 The Journal of Biological Chemistry. Nov, 2004 | Pubmed ID: 15337766 연골 Oligomeric 매트릭스 단백질 유전자에 소음 기 요소 조절 Chondrocyte 특정 식 Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Jul, 2004 | Pubmed ID: 15183430 Ileal Na + Vacuolar 프로톤 펌프의 16-kDa 소 단위 C의 협회-종속 담 즙 산 전송: 단백질-단백질 상호 작용 및 세포내 인신 매매 The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14752118 섬유 아 세포 성장 인자 동종 요소 1b 심장 나트륨 채널 Nav1.5의 변조 The Journal of Biological Chemistry. Jan, 2003 | Pubmed ID: 12401812 MyoD 유도할 수 있는 P204 단백질 Id 단백질에 의해 Myoblast 차별화의 저해를 극복 했다 Molecular and Cellular Biology. May, 2002 | Pubmed ID: 11940648 라파마이신/mTOR 상호 작용을 연구하기 위한 반정량적 약물 선호도 반응 형 표적 안정성(DARTS) 분석 Chen Zhang*1, Min Cui*1, Yazhou Cui1, Aubryanna Hettinghouse1, Chuan-ju Liu1,2 1Department of Orthopaedic Surgery, New York University Medical Center, 2Department of Cell Biology, New York University School of Medicine JoVE 59656 Biochimica 관절염에 Progranulin의 보호 역할을 조사하기 위해 마우스의 수술로 유발 된 모델 구축 Yunpeng Zhao1, Ben Liu1, Chuan-ju Liu2 1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 2Department of Orthopaedic Surgery, New York University Medical Center JoVE 50924 Bioingegneria 성장 팩터 Progranulin와 상호 작용하는 단백질을 식별하기 위해 수정된 효모 - 2 하이브리드 시스템 Qing-Yun Tian1, Yun-Peng Zhao1, Chuan-ju Liu1,2 1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 2Department of Cell Biology, New York University School of Medicine JoVE 3562 Biologia
라파마이신/mTOR 상호 작용을 연구하기 위한 반정량적 약물 선호도 반응 형 표적 안정성(DARTS) 분석 Chen Zhang*1, Min Cui*1, Yazhou Cui1, Aubryanna Hettinghouse1, Chuan-ju Liu1,2 1Department of Orthopaedic Surgery, New York University Medical Center, 2Department of Cell Biology, New York University School of Medicine JoVE 59656 Biochimica
관절염에 Progranulin의 보호 역할을 조사하기 위해 마우스의 수술로 유발 된 모델 구축 Yunpeng Zhao1, Ben Liu1, Chuan-ju Liu2 1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 2Department of Orthopaedic Surgery, New York University Medical Center JoVE 50924 Bioingegneria
성장 팩터 Progranulin와 상호 작용하는 단백질을 식별하기 위해 수정된 효모 - 2 하이브리드 시스템 Qing-Yun Tian1, Yun-Peng Zhao1, Chuan-ju Liu1,2 1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 2Department of Cell Biology, New York University School of Medicine JoVE 3562 Biologia