Daniel E. Kaufmann

Publications

• Simultaneous TCR and CD244 Signals Induce Dynamic Downmodulation of CD244 on Human Antiviral T Cells
  Journal of Immunology (Baltimore, Md. : 1950). Sep, 2013  |   Pubmed ID: 23913963
• Cutting Edge: Prolonged Exposure to HIV Reinforces a Poised Epigenetic Program for PD-1 Expression in Virus-specific CD8 T Cells
  Journal of Immunology (Baltimore, Md. : 1950). Jul, 2013  |   Pubmed ID: 23772031
• High-dimensional Immunomonitoring Models of HIV-1-specific CD8 T-cell Responses Accurately Identify Subjects Achieving Spontaneous Viral Control
  Blood. Jan, 2013  |   Pubmed ID: 23233659
• A Blueprint for HIV Vaccine Discovery
  Cell Host & Microbe. Oct, 2012  |   Pubmed ID: 23084910
• TCR Clonotypes Modulate the Protective Effect of HLA Class I Molecules in HIV-1 Infection
  Nature Immunology. Jul, 2012  |   Pubmed ID: 22683743
• CD4+ CD25+ Regulatory T Cells Impair HIV-1-specific CD4 T Cell Responses by Upregulating Interleukin-10 Production in Monocytes
  Journal of Virology. Jun, 2012  |   Pubmed ID: 22496237
• Preserved Function of Regulatory T Cells in Chronic HIV-1 Infection Despite Decreased Numbers in Blood and Tissue
  The Journal of Infectious Diseases. May, 2012  |   Pubmed ID: 22427677
• Role of PD-1 in HIV Pathogenesis and As Target for Therapy
  Current HIV/AIDS Reports. Mar, 2012  |   Pubmed ID: 22198819
• Association of IL-10-promoter Genetic Variants with the Rate of CD4 T-cell Loss, IL-10 Plasma Levels, and Breadth of Cytotoxic T-cell Lymphocyte Response During Chronic HIV-1 Infection
  Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. Jan, 2012  |   Pubmed ID: 22100578
• Detection of Intranasally Delivered Bone Marrow-derived Mesenchymal Stromal Cells in the Lesioned Mouse Brain: a Cautionary Report
  Stem Cells International. 2011  |   Pubmed ID: 22190964
• HIV Controllers: a Multifactorial Phenotype of Spontaneous Viral Suppression
  Clinical Immunology (Orlando, Fla.). Oct, 2011  |   Pubmed ID: 21865089
• High-functional-avidity Cytotoxic T Lymphocyte Responses to HLA-B-restricted Gag-derived Epitopes Associated with Relative HIV Control
  Journal of Virology. Sep, 2011  |   Pubmed ID: 21752903
• Responsiveness of HIV-specific CD4 T Cells to PD-1 Blockade
  Blood. Jul, 2011  |   Pubmed ID: 21652684
• HIV-specific CD4 T Cells and Immune Control of Viral Replication
  Current Opinion in HIV and AIDS. May, 2011  |   Pubmed ID: 21502921
• Epithelial Adhesion Molecules Can Inhibit HIV-1-specific CD8⁺ T-cell Functions
  Blood. May, 2011  |   Pubmed ID: 21403126
• Ets-1 Maintains IL-7 Receptor Expression in Peripheral T Cells
  Journal of Immunology (Baltimore, Md. : 1950). Jan, 2011  |   Pubmed ID: 21148801
• Expression of PD-L1 and PD-L2 on Human Macrophages is Up-regulated by HIV-1 and Differentially Modulated by IL-10
  Journal of Leukocyte Biology. Apr, 2011  |   Pubmed ID: 21097698
• Transcriptional Analysis of HIV-specific CD8+ T Cells Shows That PD-1 Inhibits T Cell Function by Upregulating BATF
  Nature Medicine. Oct, 2010  |   Pubmed ID: 20890291
• Protective And detrimental Roles Of IL-10 In HIV Pathogenesis
  European Cytokine Network. Sep, 2010  |   Pubmed ID: 20732847
• Impaired Replication Capacity of Acute/early Viruses in Persons Who Become HIV Controllers
  Journal of Virology. Aug, 2010  |   Pubmed ID: 20504921
• Viral Adaptation to Immune Selection Pressure by HLA Class I-restricted CTL Responses Targeting Epitopes in HIV Frameshift Sequences
  The Journal of Experimental Medicine. Jan, 2010  |   Pubmed ID: 20065065
• Inhibitory TCR Coreceptor PD-1 is a Sensitive Indicator of Low-level Replication of SIV and HIV-1
  Journal of Immunology (Baltimore, Md. : 1950). Jan, 2010  |   Pubmed ID: 19949078
• PD-1 and CTLA-4 Inhibitory Cosignaling Pathways in HIV Infection and the Potential for Therapeutic Intervention
  Journal of Immunology (Baltimore, Md. : 1950). May, 2009  |   Pubmed ID: 19414738
• IL-10 is Up-regulated in Multiple Cell Types During Viremic HIV Infection and Reversibly Inhibits Virus-specific T Cells
  Blood. Jul, 2009  |   Pubmed ID: 19365081
• Immunodominant HIV-1 Cd4+ T Cell Epitopes in Chronic Untreated Clade C HIV-1 Infection
  PloS One. 2009  |   Pubmed ID: 19352428
• In Vitro Priming Recapitulates in Vivo HIV-1 Specific T Cell Responses, Revealing Rapid Loss of Virus Reactive CD4 T Cells in Acute HIV-1 Infection
  PloS One. 2009  |   Pubmed ID: 19165342
• Programmed Death-1 As a Factor in Immune Exhaustion and Activation in HIV Infection
  Current Opinion in HIV and AIDS. May, 2008  |   Pubmed ID: 19372991
• Genetic and Immunologic Heterogeneity Among Persons Who Control HIV Infection in the Absence of Therapy
  The Journal of Infectious Diseases. Feb, 2008  |   Pubmed ID: 18275276
• Treatment Interruption to Boost Specific HIV Immunity in Acute Infection
  Current Opinion in HIV and AIDS. Jan, 2007  |   Pubmed ID: 19372861
• Increased Sequence Diversity Coverage Improves Detection of HIV-specific T Cell Responses
  Journal of Immunology (Baltimore, Md. : 1950). Nov, 2007  |   Pubmed ID: 17982054
• Upregulation of CTLA-4 by HIV-specific CD4+ T Cells Correlates with Disease Progression and Defines a Reversible Immune Dysfunction
  Nature Immunology. Nov, 2007  |   Pubmed ID: 17906628
• Lytic and Latent Antigens of the Human Gammaherpesviruses Kaposi's Sarcoma-associated Herpesvirus and Epstein-Barr Virus Induce T-cell Responses with Similar Functional Properties and Memory Phenotypes
  Journal of Virology. May, 2007  |   Pubmed ID: 17329344
• Impaired Hepatitis C Virus-specific T Cell Responses and Recurrent Hepatitis C Virus in HIV Coinfection
  PLoS Medicine. Dec, 2006  |   Pubmed ID: 17194190
• Infection of CD127+ (interleukin-7 Receptor+) CD4+ Cells and Overexpression of CTLA-4 Are Linked to Loss of Antigen-specific CD4 T Cells During Primary Human Immunodeficiency Virus Type 1 Infection
  Journal of Virology. Oct, 2006  |   Pubmed ID: 17005693
• PD-1 Expression on HIV-specific T Cells is Associated with T-cell Exhaustion and Disease Progression
  Nature. Sep, 2006  |   Pubmed ID: 16921384
• Expansion of HIV-specific CD4+ and CD8+ T Cells by Dendritic Cells Transfected with MRNA Encoding Cytoplasm- or Lysosome-targeted Nef
  Blood. Mar, 2006  |   Pubmed ID: 16249391
• Selective Escape from CD8+ T-cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution
  Journal of Virology. Nov, 2005  |   Pubmed ID: 16227247
• Early Proliferation of CCR5(+) CD38(+++) Antigen-specific CD4(+) Th1 Effector Cells During Primary HIV-1 Infection
  Blood. Sep, 2005  |   Pubmed ID: 15905189
• Limited Durability of Viral Control Following Treated Acute HIV Infection
  PLoS Medicine. Nov, 2004  |   Pubmed ID: 15526059
• Loss of HIV-1-specific CD8+ T Cell Proliferation After Acute HIV-1 Infection and Restoration by Vaccine-induced HIV-1-specific CD4+ T Cells
  The Journal of Experimental Medicine. Sep, 2004  |   Pubmed ID: 15381726
• Beyond Help: Direct Effector Functions of Human Immunodeficiency Virus Type 1-specific CD4(+) T Cells
  Journal of Virology. Aug, 2004  |   Pubmed ID: 15280492
• Fine Specificity and Cross-clade Reactivity of HIV Type 1 Gag-specific CD4+ T Cells
  AIDS Research and Human Retroviruses. Mar, 2004  |   Pubmed ID: 15117455
• Comprehensive Analysis of Human Immunodeficiency Virus Type 1-specific CD4 Responses Reveals Marked Immunodominance of Gag and Nef and the Presence of Broadly Recognized Peptides
  Journal of Virology. May, 2004  |   Pubmed ID: 15078927
• The Value of Preserving HIV-specific Immune Responses
  Journal of HIV Therapy. Feb, 2003  |   Pubmed ID: 12840711